HCK - HCK proto-oncogene, Src family tyrosine kinase Gene

Homo sapiens

Also known as JTK9; p59Hck; p61Hck

Gene ID: 3055 | Gene type: protein coding

About HCK

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,052,242-32,101,856 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 32 paralogues. Broad expression in appendix (RPKM 55.1), spleen (RPKM 40.9) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

HCK Products(6)

mRNA	Protein	Name
NM_001172129.3	NP_001165600.1	tyrosine-protein kinase HCK isoform b
NM_001172130.3	NP_001165601.1	tyrosine-protein kinase HCK isoform c
NM_001172131.3	NP_001165602.1	tyrosine-protein kinase HCK isoform d
NM_001172132.3	NP_001165603.1	tyrosine-protein kinase HCK isoform e
NM_001172133.3	NP_001165604.1	tyrosine-protein kinase HCK isoform b
NM_002110.5	NP_002101.2	tyrosine-protein kinase HCK isoform a

HCK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
506 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase HCK

hematopoietic cell kinase

Related Diseases

Diseases

Alias

Renal Pelvis Adenocarcinoma

Adenocarcinoma Of Renal Pelvis

Adenocarcinoma Of The Kidney Pelvis

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Cd45 Deficiency

Lung Clear Cell Carcinoma

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10186	TG 100801	Inhibitor	98.60%	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112852	TL02-59		99.84%	Unkown
HY-18009	(Z)-LFM-A13	Inhibitor	99.97%	Unkown
HY-139147	iHCK-37	Inhibitor	99.69%	Unkown
HY-P3279	EPQpYEEIPIYL	Activator	98.94%	Unkown
HY-155657	BT424	Inhibitor	98.81%	Unkown
HY-10185	TG 100572 Hydrochloride	Inhibitor	98.96%	Unkown
HY-D1694	LysoTracker Yellow HCK 123		98.51%	Unkown
HY-120595	JNJ-49095397	Inhibitor	99.85%	Unkown
HY-125028	Hck-IN-1	Inhibitor	98.53%	Unkown
HY-123450	S116836		99.65%	Unkown
HY-10184	TG 100572	Inhibitor	/	Unkown
HY-112852A	TL02-59 dihydrochloride		/	Unkown
HY-138562	HIV-1 Nef-IN-1	Inhibitor	98.60%	Unkown
HY-147314	HIV-IN-6	Inhibitor	98.35%	Unkown
HY-15268	PP487	Inhibitor	/	Unkown
HY-15805	KIN-8194	Inhibitor	/	Unkown
HY-RS06044	HCK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HCK	VGNC	VGNC:29774
Rattus norvegicus	HCK	RGD	RGD:2785
Canis familiaris	HCK	VGNC	VGNC:41618
Mus musculus	HCK	MGD	MGI:96052
Felis catus	HCK	VGNC	VGNC:67542
Macaca mulatta	HCK	VGNC	VGNC:73353
Others	HCK	NCBI

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