HCRTR1 - hypocretin receptor 1 Gene

Homo sapiens

Also known as OX1R; OXR1; ORXR1

Gene ID: 3061 | Gene type: protein coding

About HCRTR1

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,617,689-31,634,492 (from NCBI)

This gene has 6 transcripts (splice variants), 94 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]

HCRTR1 Products(3)

mRNA	Protein	Name
XM_024446605.2	XP_024302373.1	orexin/Hypocretin receptor type 1 isoform X1
NM_001525.3	NP_001516.2	orexin/Hypocretin receptor type 1
XM_017001107.2	XP_016856596.1	orexin/Hypocretin receptor type 1 isoform X2

HCRTR1 Protein Structure

7tm_1

0
100
200
300
400
425 a.a.

Protein Preferred Names

Protein Names

orexin/Hypocretin receptor type 1

hypocretin (orexin) receptor 1	hypocretin receptor type 1
orexin receptor 1	orexin receptor type 1

Related Diseases

Diseases

Alias

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Morphine Dependence

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Von Economo'S Disease

Encephalitis Lethargica	Von Economo Encephalitis
Von Economo Disease

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Adrenal Cortical Adenoma

Adrenocortical Adenoma

Adenoma Adrenocortical

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS06051	HCRTR1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS06052	Hcrtr1 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS06053	Hcrtr1 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HCRTR1	VGNC	VGNC:41623
Rattus norvegicus	HCRTR1	RGD	RGD:2787
Macaca mulatta	HCRTR1	VGNC	VGNC:73356
Bos taurus	HCRTR1	VGNC	VGNC:29781
Mus musculus	HCRTR1	MGD	MGI:2385650
Felis catus	HCRTR1	VGNC	VGNC:67544
Others	HCRTR1	NCBI

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