Pde12 - phosphodiesterase 12 Gene

Rattus norvegicus

Also known as 2-PDE; 2'-PDE; LRRGT00074; RGD1310975

Gene ID: 306231 | Gene type: protein coding

About Pde12

Primary_assembly 16: 1,915,386-1,925,887 reverse strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 204 orthologues, 5 paralogues and is associated with 2 phenotypes. Biased expression in Kidney (RPKM 17.6), Thymus (RPKM 84.7) and 9 other tissues.

Summary

Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in several processes, including RNA metabolic process; cellular response to cytokine stimulus; and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human PDE12 (phosphodiesterase 12). [provided by Alliance of Genome Resources, Apr 2022]

Pde12 Products(1)

mRNA	Protein	Name
NM_001411708.1	NP_001398637.1	2',5'-phosphodiesterase 12

Protein Preferred Names

Protein Names

2',5'-phosphodiesterase 12

mitochondrial deadenylase

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124768	PDE12-IN-3	Inhibitor	99.43%	Unkown
HY-117318	PDE12-IN-1	Inhibitor	99.23%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pde12	NCBI	NCBI:201626

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