KCNIP3 - potassium voltage-gated channel interacting protein 3 Gene

Homo sapiens

Also known as CSEN; DREAM; KCHIP3

Gene ID: 30818 | Gene type: protein coding

About KCNIP3

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,297,347-95,386,077 (from NCBI)

This gene has 8 transcripts (splice variants), 275 orthologues and 14 paralogues. Broad expression in brain (RPKM 13.6), thyroid (RPKM 9.3) and 14 other tissues.

Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

KCNIP3 Products(2)

mRNA	Protein	Name
NM_001034914.2	NP_001030086.1	calsenilin isoform 2 precursor
NM_013434.5	NP_038462.1	calsenilin isoform 1

KCNIP3 Protein Structure

EF-hand_8

EF-hand_7

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

calsenilin

A-type potassium channel modulatory protein 3

Recombinant KCNIP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75691	CSEN Protein, Human (His)	Q9Y2W7 (M1-I256)	≥95%

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 20

DBA20

Rps15a-Related Diamond-Blackfan Anemia

Renal Artery Obstruction

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07134	KCNIP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KCNIP3	VGNC	VGNC:73834
Bos taurus	KCNIP3	VGNC	VGNC:102823
Canis familiaris	KCNIP3	VGNC	VGNC:42256
Mus musculus	KCNIP3	MGD	MGI:1929258
Rattus norvegicus	KCNIP3	RGD	RGD:70888
Felis catus	KCNIP3	VGNC	VGNC:63042
Others	KCNIP3	NCBI

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