Dyrk2 - dual specificity tyrosine phosphorylation regulated kinase 2 Gene

Rattus norvegicus

Gene ID: 314862 | Gene type: protein coding

About Dyrk2

Primary_assembly 7: 54,349,610-54,380,106 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 208 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in Muscle (RPKM 348.9), Thymus (RPKM 336.2) and 9 other tissues.

Summary

Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and protein phosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ribonucleoprotein complex and ubiquitin ligase complex. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk2 Products(1)

mRNA	Protein	Name
NM_001108100.1	NP_001101570.1	dual specificity tyrosine-phosphorylation-regulated kinase 2

Dyrk2 Protein Structure

PKc_DYRK2_3

0
100
200
300
400
500
600 a.a.

Protein Preferred Names

Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112296	T025	Inhibitor	98.84%	Unkown
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.56%	Unkown
HY-147066	Dyrk1A-IN-4	Inhibitor	99.90%	Unkown
HY-156816	ON 108600	Inhibitor	99.73%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dyrk2	NCBI	NCBI:8445

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