HMGN2 - high mobility group nucleosomal binding domain 2 Gene

Homo sapiens

Also known as HMG17

Gene ID: 3151 | Gene type: protein coding

About HMGN2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,472,440-26,476,642 (from NCBI)

This gene has 10 transcripts (splice variants), 126 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 279.3), lymph node (RPKM 141.8) and 25 other tissues.

Summary

The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

HMGN2 Products(1)

mRNA	Protein	Name
NM_005517.4	NP_005508.1	non-histone chromosomal protein HMG-17

HMGN2 Protein Structure

HMG14_17

0
90 a.a.

Protein Preferred Names

Protein Names

non-histone chromosomal protein HMG-17

high mobility group nucleosome-binding domain-containing protein 2

Related Diseases

Diseases

Alias

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06244	HMGN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HMGN2	MGD	MGI:96136
Bos taurus	HMGN2	VGNC	VGNC:50536
Rattus norvegicus	HMGN2	RGD	RGD:620649

Name
Email *

	Sorry, but the email address you supplied was invalid.