FOXA3 - forkhead box A3 Gene

Homo sapiens

Also known as FKHH3; HNF3G; TCF3G

Gene ID: 3171 | Gene type: protein coding

About FOXA3

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,864,326-45,873,797 (from NCBI)

This gene has 2 transcripts (splice variants), 89 orthologues and 42 paralogues. Biased expression in liver (RPKM 21.0), stomach (RPKM 17.8) and 6 other tissues.

Summary

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

FOXA3 Products(1)

mRNA	Protein	Name
NM_004497.3	NP_004488.2	hepatocyte nuclear factor 3-gamma

FOXA3 Protein Structure

Forkhead_N

Forkhead

HNF_C

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 3-gamma

HNF-3-gamma

Related Diseases

Diseases

Alias

Adult Acute Monocytic Leukemia

Adult Acute Monoblastic And Acute Monocytic Leukemia

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05038	FOXA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FOXA3	VGNC	VGNC:29079
Felis catus	FOXA3	VGNC	VGNC:67602
Macaca mulatta	FOXA3	VGNC	VGNC:72709
Canis familiaris	FOXA3	VGNC	VGNC:40945
Mus musculus	FOXA3	MGD	MGI:1347477
Rattus norvegicus	FOXA3	RGD	RGD:2809

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