APEH - acylaminoacyl-peptide hydrolase Gene

Homo sapiens

Also known as APH; OPH; AARE; ACPH; D3S48E; D3F15S2; DNF15S2

Gene ID: 327 | Gene type: protein coding

About APEH

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,673,117-49,683,971 (from NCBI)

This gene has 16 transcripts (splice variants), 189 orthologues and 6 paralogues. Ubiquitous expression in kidney (RPKM 28.3), thyroid (RPKM 22.2) and 25 other tissues.

Summary

This gene encodes the Enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated Peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]

APEH Products(1)

mRNA	Protein	Name
NM_001640.4	NP_001631.3	acylamino-acid-releasing enzyme

APEH Protein Structure

Peptidase_S9

0
200
400
600
732 a.a.

Protein Preferred Names

Protein Names

acylamino-acid-releasing enzyme

N-acylaminoacyl-peptide hydrolase

Related Diseases

Diseases

Alias

Campylobacteriosis

Campylobacter Infections	Campylobacter Infection
Enteric Campylobacteriosis

Barbiturate Dependence

Endocardium Disease

Myasthenic Syndrome, Congenital, 22

CMS22	Prepl Deficiency
Congenital Myasthenic Syndrome 22

Urinary Tract Infection

Urinary Tract Infections	Uti
Urinary Tract Infection Nos	Uti - [Urinary Tract Infection]
Uti Nos - [Urinary Tract Infection Nos]	Urosepsis Nos
E Coli Uti	E Coli Urinary Tract Infection
Escherichia Coli Uti

Salmonellosis

Salmonella Infections

Salmonella Infection

Infective Endocarditis

Bacterial Endocarditis	Endocarditis, Infective
Infectious Endocarditis	Endocarditis Infective

Hypotonia-Cystinuria Syndrome

Cystinuria With Mitochondrial Disease	2p21 Microdeletion Syndrome
HCS	Homozygous 2p16 Deletion Syndrome, Formerly
2p21 Deletion Syndrome	Del(2)(P21)
Monosomy 2p21	Atypical Hypotonia-Cystinuria Syndrome
Atypical Hcs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134932	AA74-1		≥98.0%	Unkown
HY-RS00813	APEH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	APEH	VGNC	VGNC:67739
Bos taurus	APEH	VGNC	VGNC:26010
Rattus norvegicus	APEH	RGD	RGD:2125
Macaca mulatta	APEH	VGNC	VGNC:69982
Mus musculus	APEH	MGD	MGI:88041
Canis familiaris	APEH	VGNC	VGNC:37982

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