1. Gene
  2. HRH2 - histamine receptor H2 Gene

HRH2 - histamine receptor H2 Gene

Homo sapiens

Also known as H2R; HH2R

Gene ID: 3274 | Gene type: protein coding

About HRH2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:175,658,071-175,710,756 (from NCBI)

This gene has 3 transcripts (splice variants), 249 orthologues and 25 paralogues. Broad expression in bone marrow (RPKM 7.6), heart (RPKM 5.0) and 18 other tissues.

Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine Receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

HRH2 Products(9)

mRNA Protein Name
NR_171689.1
NR_160284.1
XM_006714865.4 XP_006714928.1 histamine H2 receptor isoform X2
NM_022304.2
NM_001393461.1 NP_001380390.1 histamine H2 receptor isoform 1
NM_001131055.2 NP_001124527.1 histamine H2 receptor isoform 1
NM_001367711.1 NP_001354640.1 histamine H2 receptor isoform 2
NM_001393460.1 NP_001380389.1 histamine H2 receptor isoform 1
XM_011534549.4 XP_011532851.1 histamine H2 receptor isoform X1

HRH2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (35 - 288)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

histamine H2 receptor

gastric receptor 1

gastric receptor I

Related Diseases

Diseases Alias
Peptic Esophagitis

Reflux Esophagitis

Peptic Reflux Disease

Reflux Oesophagitis

Esophagitis, Peptic

Gastro-Esophageal Reflux Disease With Esophagitis

Laryngitis

Acute Laryngitis

Gastroparesis

Gastroparesis Syndrome

Delayed Gastric Emptying

Gastric Atonia

Gastroparalysis

Duodenogastric Reflux
Chronic Laryngitis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Duodenal Gastrinoma

Duodenal G-Cell Gastrin Producing Tumor

Gastrinoma Of Duodenum

Malignant Duodenal Gastrinoma

Duodenal Gastrin-Producing Neuroendocrine Tumor

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Pancreatic Gastrinoma

Pancreatic G-Cell Tumor

Aspiration Pneumonitis

Chemical Pneumonitis

Mendelson'S Syndrome

Aspiration Pneumonia

Pneumonitis Due To Fumes And/Or Vapors

Toxic Pneumonitis

Mendelson'S Syndrome Resulting From A Procedure

Mendelson Syndrome Resulting From A Procedure

Pulmonary Acid Aspiration Syndrome

Pneumonitis Due To Inhalation Of Gastric Secretions

Mendelson Syndrome Due To Anaesthesia During Labour And Delivery

Inhalation Of Stomach Contents Or Secretions, Nos Due To Anaesthesia During Labour And Delivery

Necrotizing Gastritis
Zollinger-Ellison Syndrome

Gastrinoma

Pancreatic Ulcerogenic Tumor Syndrome

Z E Syndrome

Zes

Ze - [Zollinger-Ellison] Syndrome

Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux

Gastroenteritis

Cholera Morbus

Infectious Colitis, Enteritis And Gastroenteritis

Enteritis Due To Astrovirus

Rotaviral Gastroenteritis

Viral Gastroenteritis Due To Rotavirus

Hernia, Hiatus

Hiatal Hernia

Hiatus Hernia

Diaphragmatic - Hiatus -Hernia

Hernia, Hiatal

Duodenal Ulcer

Stress Ulcer

Curling Ulcer

Stress Ulcer Of Stomach

Curling'S Ulcers

Duodenal Ulcer Disease

Duodenal Ulcers

Duodenal Peptic Ulcer

Cascade Stomach

Hourglass Stricture Or Stenosis Of Stomach

Hourglass Contraction Of Stomach

Hourglass Stenosis Of Stomach

Hourglass Stricture Of Stomach

Internal Hordeolum
Bacterial Gastritis
Peptic Ulcer Disease

Peptic Ulcer

Acute Peptic Ulcer With Hemorrhage

Acute Peptic Ulcer With Hemorrhage And Perforation

Acute Peptic Ulcer Without Hemorrhage And Without Perforation

Dyskinesia Of Esophagus

Esophageal Motility Disorders

Dyskinesia Of Oesophagus

Esophageal Dysmotility

Esophageal Motility Disorder

Oesophageal Dysmotility

Oesophageal Motor Disorder

Esophageal Spasm

Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease

Stomach Disease

Gastropathy

Stomach Diseases

Gastric Disease

Stomach Disorder

Gastric Disorder

Stomach Disorders

Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos

Peptic Ulcer Perforation

Perforated Peptic Ulcer

Acute Peptic Ulcer With Perforation

Peptic Ulcer With Perforation

Active Peptic Ulcer Disease

Gi Bleeding

Active Peptic Ulcer

Gastrointestinal Hemorrhage

Gastric Ulcer

Stomach Ulcer

Acute Gastric Ulcer With Haemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction

Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction

Acute Gastric Ulcer With Hemorrhage, With Obstruction

Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction

Acute Gastric Ulcer With Perforation

Acute Gastric Ulcer With Perforation And Obstruction

Acute Gastric Ulcer With Perforation, With Obstruction

Acute Gastric Ulcer Without Hemorrhage And Without Perforation

Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

Bleeding Acute Gastric Ulcer

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction

Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction

Gastric Ulcers

Cushings Ulcer

Cushing'S Ulcer Of Stomach

Peptic Ulcer Of Stomach

Mucosal Defect Of The Stomach

Pancreatic Cholera

Excessive Vasoactive Intestinal Peptide Secretion

Pancreatic Wdha Syndrome

Verner-Morrison Syndrome

Esophagitis

Acute Esophagitis

Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HRH2 RGD RGD:2831
Bos taurus HRH2 VGNC VGNC:29954
Felis catus HRH2 VGNC VGNC:67650
Mus musculus HRH2 MGD MGI:108482
Canis familiaris HRH2 VGNC VGNC:41787
Macaca mulatta HRH2 VGNC VGNC:73523