FIGLA - folliculogenesis specific bHLH transcription factor Gene

Homo sapiens

Also known as POF6; BHLHC8; FIGALPHA

Gene ID: 344018 | Gene type: protein coding

About FIGLA

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,777,310-70,790,643 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues, 13 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]

FIGLA Products(1)

mRNA	Protein	Name
NM_001004311.3	NP_001004311.2	factor in the germline alpha

FIGLA Protein Structure

HLH

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

factor in the germline alpha

class C basic helix-loop-helix protein 8

Related Diseases

Diseases

Alias

Premature Ovarian Failure 6

POF6	Ovarian Failure, Premature, Type 6

Genetic Non-Acquired Premature Ovarian Failure

Ovarian Dysgenesis 2

Premature Ovarian Failure 4	ODG2
Ovarian Dysgenesis, Hypergonadotropic, X-Linked	Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis
Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis	X-Linked Hypergonadotropic Ovarian Dysgenesis
POF4	Dysgenesis, Ovarian, Type 2

46 Xx Gonadal Dysgenesis

Ovarian Dysgenesis	Gonadal Dysgenesis, 46,Xx
Dysgenesis, Ovarian

Amenorrhea

Absence Of Menstruation

Amenia

Hermaphroditism

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome	Deafness-Hermann Type Symphalangism Syndrome
Facio-Audio-Symphalangism	Hearing Loss-Hermann Type Symphalangism Syndrome
Wl Syndrome	Multiple Synostosis Syndrome

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04945	FIGLA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FIGLA	VGNC	VGNC:72563
Canis familiaris	FIGLA	VGNC	VGNC:54149
Mus musculus	FIGLA	MGD	MGI:1349421
Bos taurus	FIGLA	VGNC	VGNC:29009
Felis catus	FIGLA	VGNC	VGNC:80099
Rattus norvegicus	FIGLA	RGD	RGD:1564754

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