NOTO - notochord homeobox Gene

Homo sapiens

Gene ID: 344022 | Gene type: protein coding

About NOTO

This gene has 1 transcript (splice variant), 90 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in central nervous system development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic organ development; motile cilium assembly; and regulation of cilium assembly. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NOTO Products(1)

mRNA	Protein	Name
NM_001134462.2	NP_001127934.1	homeobox protein notochord

NOTO Protein Structure

Homeobox

0
100
200
251 a.a.

Protein Preferred Names

Protein Names

homeobox protein notochord

notochord homolog

Related Diseases

Diseases

Alias

Epilepsy, Familial Temporal Lobe, 4

ETL4	Epilepsy, Occipitotemporal Lobe, And Migraine With Aura
Epolm	Familial Temporal Lobe Epilepsy 4
Occipitotemporal Lobe Epilepsy And Migraine With Aura

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09453	NOTO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NOTO	RGD	RGD:1562910
Macaca mulatta	NOTO	VGNC	VGNC:106189
Bos taurus	NOTO	VGNC	VGNC:32180
Mus musculus	NOTO	MGD	MGI:3053002

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