EVX2 - even-skipped homeobox 2 Gene

Homo sapiens

Also known as EVX-2

Gene ID: 344191 | Gene type: protein coding

About EVX2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:176,077,472-176,083,962 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues and 50 paralogues. Low expression observed in reference dataset.

Summary

This gene is located at the 5' end of the HOXD gene cluster on chromosome 2. The encoded protein is a homeobox transcription factor that is related to the protein encoded by the Drosophila even-skipped (eve) gene, a member of the pair-rule class of segmentation genes. A 117 kb microdeletion at the 5' end of the HOXD gene cluster, which includes this gene and the HOXD9-HOXD13 genes, causes synpolydactyly, a dominantly inherited disease resulting in limb malformation. [provided by RefSeq, Sep 2009]

EVX2 Products(1)

mRNA	Protein	Name
NM_001080458.2	NP_001073927.1	homeobox even-skipped homolog protein 2

EVX2 Protein Structure

Homeobox

0
100
200
300
400
476 a.a.

Protein Preferred Names

Protein Names

homeobox even-skipped homolog protein 2

eve, even-skipped homeo box homolog 2

Related Diseases

Diseases

Alias

Synpolydactyly

Syndactyly Type 2	Syndactyly, Type 2
Spd

Split-Hand/Foot Malformation 6

Split Hand-Foot Malformation 6	SHFM6
Ectrodactyly, Autosomal Recessive	Ectrodactyly Autosomal Recessive
Split-Hand/Foot Malformation, Type 6

Split-Hand/Foot Malformation 5

Split Hand-Foot Malformation 5

SHFM5

Split-Hand/Foot Malformation 2

SHFM2	Shfd2
Shsf2	Split Hand/Foot Malformation 2
Split Hand-Foot Malformation 2	Split-Hand/Split-Foot Anomaly, X-Linked
Split-Hand/Foot Deformity 2	Split Hand/Foot Malformation X-Linked
Split Hand Foot Anomaly - X-Linked	Split Hand Foot Deformity 2

Brachydactyly, Type A3

Brachydactyly Type A3	BDA3
Brachydactyly-Clinodactyly	Brachymesophalangy V
Brachymesophalangy 5	Brachydactyly Clinodactyly

Split-Hand/Foot Malformation 4

SHFM4	Split Hand-Foot Malformation 4
Split-Hand/Foot Malformation, Type 4

Split Hand-Foot Malformation

Ectrodactyly	Split-Hand/Foot Malformation
Lobster-Claw Deformity	Split-Hand Deformity
Split Hand Foot Malformation	Shfm
Split Hand Foot Deformity	Split Hand Foot Deformity 1

Brachydactyly, Type D

Brachydactyly Type D	BDD
Stub Thumb	Brachydactyly D

Chromosome 2q35 Duplication Syndrome

Syndactyly	Syndactyly Type 1
Sdty1	Zygodactyly
Syndactyly, Type I	Sd1
Syndactyly, Type 1, With Or Without Craniosynostosis	Symphalangism
Non-Syndromic Syndactyly	Symphalangy
Webbing Of Digits	Syndactyly, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04580	EVX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EVX2	VGNC	VGNC:106727
Rattus norvegicus	EVX2	RGD	RGD:1305594
Macaca mulatta	EVX2	VGNC	VGNC:104527
Felis catus	EVX2	VGNC	VGNC:61993
Canis familiaris	EVX2	VGNC	VGNC:40507
Mus musculus	EVX2	MGD	MGI:95462

Name
Email *

	Sorry, but the email address you supplied was invalid.