CTU2 - cytosolic thiouridylase subunit 2 Gene

Homo sapiens

Also known as MFRG; NCS2; UPF0432; C16orf84

Gene ID: 348180 | Gene type: protein coding

About CTU2

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,706,503-88,715,396 (from NCBI)

This gene has 10 transcripts (splice variants), 193 orthologues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 3.9), brain (RPKM 2.8) and 25 other tissues.

Summary

This gene encodes a protein which is involved in the post-transcriptional modification of transfer RNAs (tRNAs). The encoded protein plays a role in thiolation of uridine residue present at the wobble position in a subset of tRNAs, resulting in enhanced codon reading accuracy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CTU2 Products(4)

mRNA	Protein	Name
NM_001012759.3	NP_001012777.1	cytoplasmic tRNA 2-thiolation protein 2 isoform 1
NM_001012762.3	NP_001012780.1	cytoplasmic tRNA 2-thiolation protein 2 isoform 2
NM_001318507.2	NP_001305436.1	cytoplasmic tRNA 2-thiolation protein 2 isoform 3
NM_001318513.2	NP_001305442.1	cytoplasmic tRNA 2-thiolation protein 2 isoform 4

CTU2 Protein Structure

CTU2

0
100
200
300
400
515 a.a.

Protein Preferred Names

Protein Names

cytoplasmic tRNA 2-thiolation protein 2

cytosolic thiouridylase subunit 2 homolog

Related Diseases

Diseases

Alias

Microcephaly, Facial Dysmorphism, Renal Agenesis, And Ambiguous Genitalia Syndrome

MFRG

Peroneal Neuropathy

Peroneal Neuropathies

Cakut

Renal Or Urinary Tract Malformation	Congenital Anomalies Of Kidney And Urinary Tract
Congenital Anomaly Of Kidney And Urinary Tract	Congenital Anomalies Of The Kidney And Urinary Tract
Kidney And Urinary Tract, Anomalies, Congenital	Renal Hypodysplasia, Nonsyndromic, 1

Phobia, Specific

Specific Phobia	Simple Phobia
Phobia, Simple	Isolated Phobia

Primary Microcephaly

True Microcephaly

Microcephaly, Primary

Dysthymic Disorder

Dysthymia	Chronic Depressive Disorder
Chronic Depression	Depressive Personality
Depressive Personality Disorder	Persistent Depressive Disorder
Persistent Depression

Social Phobia

Phobia, Social	Phobia Social
Phobic Anxiety Disorder

Intermittent Explosive Disorder

Explosive Personality Disorder

Phobic Disorder

Phobic Disorders

Phobic Anxiety Disorder

Sucrase-Isomaltase Deficiency, Congenital

Congenital Sucrase-Isomaltase Deficiency	CSID
Si Deficiency	Congenital Sucrose Intolerance
Disaccharide Intolerance	Sucrase-Isomaltase Deficiency
Disaccharide Intolerance I	Congenital Sucrose-Isomaltose Malabsorption
Sucrose-Isomaltose Malabsorption, Congenital	Sucrose Intolerance, Congenital
Congenital Sucrase-Isomaltose Malabsorption	Congenital Sucrose-Isomaltase Malabsorption
Disaccharide Intolerance, 1	Sucrose Intolerance Congenital
Sucrose-Isomaltase Malabsorption, Congenital	Disaccharidase Deficiency
Invertase Deficiency	Sucrase-Alpha-Dextrinase Deficiency
Disaccharide Intolerance Type I	Csid - [Congenital Sucrase-Isomaltase Deficiency]
Sucrose Intolerance Of Newborn	Sucrose Intolerance
Sucrase Deficiency	Disaccharide Malabsorption
Intestinal Disaccharidase Deficiency

Hymenolepiasis

Dwarf Tapeworm Infection	Hymenolepis Infectious Disease
Hymenolepsis Infection	Hyemolepis Nana Infection
Hymenolepiosis	Hymenolepis Infection
Dwarf Tapeworm	Hymenolepidosis
Hymenolepis Infestation

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Separation Anxiety Disorder

Separation Anxiety Disorder Of Childhood

Generalized Anxiety Disorder

Anxiety Generalized

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies	Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies
Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome	Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03354	CTU2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CTU2	RGD	RGD:1562594
Mus musculus	CTU2	MGD	MGI:1914215
Felis catus	CTU2	VGNC	VGNC:61276
Canis familiaris	CTU2	VGNC	VGNC:39721
Bos taurus	CTU2	VGNC	VGNC:27824
Macaca mulatta	CTU2	VGNC	VGNC:71598