2. Gene
  3. NMNAT3 - nicotinamide nucleotide adenylyltransferase 3 Gene

NMNAT3 - nicotinamide nucleotide adenylyltransferase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PNAT3; FKSG76; PNAT-3

Gene ID: 349565 | Gene type: protein coding

About NMNAT3

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:139,560,180-139,678,050 (from NCBI)

This gene has 22 transcripts (splice variants), 195 orthologues and 2 paralogues. Broad expression in ovary (RPKM 2.3), testis (RPKM 2.2) and 24 other tissues.

Summary

This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

NMNAT3 Products(22)

mRNA Protein Name
NM_001200047.3 NP_001186976.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 2
NM_001320510.2 NP_001307439.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 3
NM_001320511.2 NP_001307440.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 4
NM_001320512.2 NP_001307441.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 4
NM_001320513.2 NP_001307442.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 5
NM_001363968.1 NP_001350897.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 6
NM_001401598.1 NP_001388527.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 3
NM_001401599.1 NP_001388528.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 3
NM_001401600.1 NP_001388529.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 4
NM_001401601.1 NP_001388530.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 4
NM_001401602.1 NP_001388531.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 4
NM_001401603.1 NP_001388532.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 4
NM_001401604.1 NP_001388533.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 1
NM_001401605.1 NP_001388534.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 7
NM_001401606.1 NP_001388535.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 7
NM_001401607.1 NP_001388536.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 6
NM_001401608.1 NP_001388537.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 6
NM_001401609.1 NP_001388538.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 8
NM_001401610.1 NP_001388539.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 8
NM_001401611.1 NP_001388540.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 8
NM_001401612.1 NP_001388541.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 8
NM_178177.5 NP_835471.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 isoform 1

NMNAT3 Protein Structure

CTP_transf_like

CTP_transf_like: Cytidylyltransferase-like (10 - 208)

  • 0
  • 100
  • 200
  • 252 a.a.
Protein Preferred Names Protein Names

nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

NMN adenylyltransferase 3

Related Diseases

Diseases Alias
Leber Congenital Amaurosis 9

LCA9

Leber Congenital Amaurosis, Type 9
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09384 NMNAT3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NMNAT3 VGNC VGNC:75224
Mus musculus NMNAT3 MGD MGI:1921330
Rattus norvegicus NMNAT3 RGD RGD:1309140
Canis familiaris NMNAT3 VGNC VGNC:43864