IL9R - interleukin 9 receptor Gene

Homo sapiens

Also known as CD129; IL-9R

Gene ID: 3581 | Gene type: protein coding

About IL9R

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,997,696-156,013,020 (from NCBI)

This gene has 4 transcripts (splice variants), 172 orthologues and 7 paralogues. Biased expression in urinary bladder (RPKM 2.4), lymph node (RPKM 1.3) and 11 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

IL9R Products(2)

mRNA	Protein	Name
NM_002186.3	NP_002177.2	interleukin-9 receptor isoform 1 precursor
NM_176786.2	NP_789743.2	interleukin-9 receptor isoform 2

Protein Preferred Names

Protein Names

interleukin-9 receptor

IL-9 receptor

Related Diseases

Diseases

Alias

Deafness, Y-Linked 2

DFNY2

Y-Linked Deafness 2

Bronchitis

Chronic Bronchitis	Acute Bronchitis
Bronchitis, Chronic	Acute Bronchitis And Bronchiolitis
Chest Cold	Chest Infection
Ci - Chest Infection	Recurrent Wheezy Bronchitis
Bronchitis Chronic	Lower Respiratory Tract Infection
Acute Lower Respiratory Tract Infection	Chronic Bronchitis Nos
Senile Bronchitis	Bronchitis Nos In Those Under L5 Years Of Age
Bronchitis Nos

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06782	IL9R Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL9R	MGD	MGI:96564
Rattus norvegicus	IL9R	RGD	RGD:2907
Bos taurus	IL9R	VGNC	VGNC:30172
Macaca mulatta	IL9R	VGNC	VGNC:81422
Felis catus	IL9R	VGNC	VGNC:67788
Others	IL9R	NCBI