2. Gene
  3. Prkdc - protein kinase, DNA-activated, catalytic subunit Gene

Prkdc - protein kinase, DNA-activated, catalytic subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 360748 | Gene type: protein coding

About Prkdc

Primary_assembly 11: 85,040,792-85,257,952 reverse strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 188 orthologues, 5 paralogues and is associated with 21 phenotypes. Biased expression in Thymus (RPKM 176.7), Spleen (RPKM 15.5) and 9 other tissues.

Summary

Predicted to enable several functions, including DNA-dependent protein kinase activity; Enzyme binding activity; and nucleic acid binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of cellular senescence; and negative regulation of response to gamma radiation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of several cellular components, including DNA-dependent protein kinase-DNA ligase 4 complex; protein-DNA complex; and small-subunit processome. Predicted to be active in nucleus. Used to study severe combined immunodeficiency. Human ortholog(s) of this gene implicated in immunodeficiency 26. Orthologous to human PRKDC (protein kinase, DNA-activated, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Prkdc Products(1)

mRNA Protein Name
NM_001108327.2 NP_001101797.2 DNA-dependent protein kinase catalytic subunit

Prkdc Protein Structure

NUC194

NUC194: pfam08163 (1812 - 2195)

DNAPKcs_CC5

DNAPKcs_CC5: pfam19704 (2206 - 2888)

FAT

FAT: pfam02259 (3086 - 3470)

TEL1

TEL1: cl34875 (3456 - 4012)

PIKKc_DNA-PK

PIKKc_DNA-PK: cd05172 (3716 - 4011)

FATC

FATC: pfam02260 (4095 - 4125)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4126 a.a.
Protein Preferred Names Protein Names

DNA-dependent protein kinase catalytic subunit

protein kinase, DNA activated, catalytic polypeptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11151 PRKDC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11152 Prkdc Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS11153 Prkdc Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkdc NCBI NCBI:5591