2. Gene
  3. Irak1 - interleukin-1 receptor-associated kinase 1 Gene

Irak1 - interleukin-1 receptor-associated kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1563841

Gene ID: 363520 | Gene type: protein coding

About Irak1

Primary_assembly X: 151,768,777-151,778,521 reverse strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 187 orthologues, 4 paralogues and is associated with 24 phenotypes. Biased expression in Kidney (RPKM 194.8), Adrenal (RPKM 179.6) and 9 other tissues.

Summary

Enables heat shock protein binding activity and protein kinase activity. Involved in several processes, including JNK cascade; cellular response to lipopolysaccharide; and positive regulation of smooth muscle cell proliferation. Located in membrane. Biomarker of brain ischemia and cognitive disorder. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Irak1 Products(1)

mRNA Protein Name
NM_001127555.1 NP_001121027.1 interleukin-1 receptor-associated kinase 1

Irak1 Protein Structure

Death_IRAK1

Death_IRAK1: cd08794 (16 - 99)

PKc_like

PKc_like: cl21453 (218 - 521)

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  • 711 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0039 Ginsenoside Rb1 Inhibitor 98.75% Unkown
HY-103017 JH-X-119-01 hydrochloride Inhibitor 98.15% Unkown
HY-147141 HS-276 Inhibitor 98.59% Unkown
HY-103017A JH-X-119-01 Inhibitor ≥98.0% Unkown
HY-111101 AZ1495 Inhibitor 98.18% Unkown
HY-134911 HS-243 Inhibitor 99.88% Unkown
HY-153188 JNJ-1013 Degrader 99.80% Unkown
HY-153110A Larotinib mesylate hydrate Inhibitor 98.66% Unkown
HY-153224 GLPG2534 Inhibitor 98.05% Unkown
HY-153110 Larotinib Inhibitor / Unkown
HY-160487 KME-2780 Inhibitor / Unkown
HY-N0039R Ginsenoside Rb1 (Standard) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak1 NCBI NCBI:3654