2. Gene
  3. ITIH2 - inter-alpha-trypsin inhibitor heavy chain 2 Gene

ITIH2 - inter-alpha-trypsin inhibitor heavy chain 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as H2P; SHAP

Gene ID: 3698 | Gene type: protein coding

About ITIH2

Cytogenetic location: 10p14 Genomic coordinates (GRCh38): 10:7,703,316-7,749,520 (from NCBI)

This gene has 6 transcripts (splice variants), 211 orthologues and 11 paralogues. Restricted expression toward liver (RPKM 486.6).

Summary

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine Protease Inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a LIGHT chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

ITIH2 Products(1)

mRNA Protein Name
NM_002216.3 NP_002207.2 inter-alpha-trypsin inhibitor heavy chain H2 precursor

ITIH2 Protein Structure

VIT

VIT: Vault protein inter-alpha-trypsin domain (68 - 185)

VWA

VWA: von Willebrand factor type A domain (310 - 477)

ITI_HC_C

ITI_HC_C: Inter-alpha-trypsin inhibitor heavy chain C-terminus (735 - 921)

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  • 946 a.a.
Protein Preferred Names Protein Names

inter-alpha-trypsin inhibitor heavy chain H2

ITI heavy chain H2

Related Diseases

Diseases Alias
Thrombophilia Due To Hrg Deficiency

Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency

Hereditary Thrombophilia Due To Congenital Hrg Deficiency

Thph11
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06975 ITIH2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ITIH2 MGD MGI:96619
Macaca mulatta ITIH2 VGNC VGNC:73794
Felis catus ITIH2 VGNC VGNC:67860
Canis familiaris ITIH2 VGNC VGNC:42146
Rattus norvegicus ITIH2 RGD RGD:1565426
Bos taurus ITIH2 VGNC VGNC:50202