1. Gene
  2. ITIH3 - inter-alpha-trypsin inhibitor heavy chain 3 Gene

ITIH3 - inter-alpha-trypsin inhibitor heavy chain 3 Gene

Homo sapiens

Also known as H3P; SHAP; ITI-HC3

Gene ID: 3699 | Gene type: protein coding

About ITIH3

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,794,796-52,808,797 (from NCBI)

This gene has 11 transcripts (splice variants), 299 orthologues and 11 paralogues. Restricted expression toward liver (RPKM 228.8).

Summary

This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3. [provided by RefSeq, Jul 2015]

ITIH3 Products(10)

mRNA Protein Name
NM_001392019.1 NP_001378948.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 1 precursor
NM_001392020.1 NP_001378949.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 2 precursor
NM_001392021.1 NP_001378950.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 3 precursor
NM_001392022.1 NP_001378951.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 5 precursor
NM_001392023.1 NP_001378952.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 6 precursor
NM_001392024.1 NP_001378953.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 7 precursor
NM_001392025.1 NP_001378954.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 8 precursor
NM_001392026.1 NP_001378955.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 9 precursor
NM_001392027.1 NP_001378956.1 inter-alpha-trypsin inhibitor heavy chain H3 isoform 10 precursor
NM_002217.4 NP_002208.3 inter-alpha-trypsin inhibitor heavy chain H3 isoform 4 preproprotein

ITIH3 Protein Structure

VIT

VIT: Vault protein inter-alpha-trypsin domain (41 - 158)

VWA

VWA: von Willebrand factor type A domain (284 - 456)

ITI_HC_C

ITI_HC_C: Inter-alpha-trypsin inhibitor heavy chain C-terminus (685 - 871)

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  • 890 a.a.
Protein Preferred Names Protein Names

inter-alpha-trypsin inhibitor heavy chain H3

ITI heavy chain H3

Recombinant ITIH3 Proteins

Cat. No. Product Name Accession Purity
HY-P70407 ITIH3 Protein, Human (HEK293, His) Q06033 (L35-D651) ≥95%

Related Diseases

Diseases Alias
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Immunoglobulin Heavy-And-Light Chain

Ah/Al Amyloidosis

Ig Heavy-And-Light-Chain Amyloidosis

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus ITIH3 MGD MGI:96620
Macaca mulatta ITIH3 VGNC VGNC:73795
Felis catus ITIH3 VGNC VGNC:67861
Rattus norvegicus ITIH3 RGD RGD:620633
Bos taurus ITIH3 VGNC VGNC:30335
Canis familiaris ITIH3 VGNC VGNC:103686
Others ITIH3 NCBI