1. Gene
  2. KCNA6 - potassium voltage-gated channel subfamily A member 6 Gene

KCNA6 - potassium voltage-gated channel subfamily A member 6 Gene

Homo sapiens

Also known as HBK2; KV1.6; PPP1R96

Gene ID: 3742 | Gene type: protein coding

About KCNA6

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:4,809,334-4,851,112 (from NCBI)

This gene has 1 transcript (splice variant), 82 orthologues and 31 paralogues. Biased expression in brain (RPKM 7.0), adrenal (RPKM 1.0) and 4 other tissues.

Summary

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related Potassium Channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the Potassium Channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]

KCNA6 Products(1)

mRNA Protein Name
NM_002235.5 NP_002226.1 potassium voltage-gated channel subfamily A member 6

KCNA6 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (44 - 132)

Ion_trans

Ion_trans: Ion transport protein (266 - 457)

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  • 529 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily A member 6

human brain potassium channel-2

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KCNA6 RGD RGD:62083
Mus musculus KCNA6 MGD MGI:96663
Canis familiaris KCNA6 VGNC VGNC:57428
Bos taurus KCNA6 VGNC VGNC:56213
Felis catus KCNA6 VGNC VGNC:84043
Macaca mulatta KCNA6 VGNC VGNC:108354