2. Gene
  3. NRROS - negative regulator of reactive oxygen species Gene

NRROS - negative regulator of reactive oxygen species Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GARPL1; LRRC33; SENEBAC; UNQ3030; ELLP3030

Gene ID: 375387 | Gene type: protein coding

About NRROS

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:196,639,694-196,662,004 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 13.1), spleen (RPKM 8.2) and 22 other tissues.

Summary

Enables transforming growth factor beta binding activity. Predicted to be involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta1 activation. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

NRROS Products(1)

mRNA Protein Name
NM_198565.3 NP_940967.1 transforming growth factor beta activator LRRC33 precursor

NRROS Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (134 - 156)

LRR_8

LRR_8: Leucine rich repeat (157 - 217)

LRR_8

LRR_8: Leucine rich repeat (330 - 388)

LRR_6

LRR_6: Leucine Rich repeat (426 - 439)

(463 - 478)

(536 - 552)

LRR_1

LRR_1: Leucine Rich Repeat (560 - 575)

  • 0
  • 200
  • 400
  • 600
  • 692 a.a.
Protein Preferred Names Protein Names

transforming growth factor beta activator LRRC33

glycoprotein A repetitions predominant like 1

Recombinant NRROS Proteins

Cat. No. Product Name Accession Purity
HY-P72063 NRROS Protein, Human (Baculovirus, His-Myc) Q86YC3 (W19-L650) ≥95%
HY-P72063A NRROS Protein, Human Q86YC3 (W19-L650) /

Related Diseases

Diseases Alias
Seizures, Early-Onset, With Neurodegeneration And Brain Calcifications

Seizures, Early-Onset, With Neurodegeneration And Brain Calcification

SENEBAC
Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency

IMD46

Cid Due To Tfrc Deficiency

Combined Immunodeficiency Due To Tfrc Deficiency
Chromosome 3q29 Deletion Syndrome

Chromosome 3q29 Microdeletion Syndrome

3q29 Microdeletion Syndrome

3q Subtelomere Deletion Syndrome

3q29 Recurrent Deletion

3qter Deletion

3q29 Deletion Syndrome

Monosomy 3q29

Microdeletion 3q29 Syndrome

Del(3)(Q29)

Monosomy 3qter

3q29 Deletion

Del3q29
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09581 NRROS Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NRROS VGNC VGNC:63883
Macaca mulatta NRROS VGNC VGNC:75456
Rattus norvegicus NRROS RGD RGD:1310771
Bos taurus NRROS VGNC VGNC:53592
Mus musculus NRROS MGD MGI:2445095
Others NRROS NCBI