KCNJ14 - potassium inwardly rectifying channel subfamily J member 14 Gene

Homo sapiens

Also known as IRK4; KIR2.4

Gene ID: 3770 | Gene type: protein coding

About KCNJ14

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,455,574-48,466,980 (from NCBI)

This gene has 2 transcripts (splice variants), 174 orthologues and 15 paralogues. Broad expression in testis (RPKM 1.5), skin (RPKM 1.2) and 21 other tissues.

Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type Potassium Channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]

KCNJ14 Products(1)

mRNA	Protein	Name
NM_013348.4	NP_037480.1	ATP-sensitive inward rectifier potassium channel 14

KCNJ14 Protein Structure

IRK

0
100
200
300
400
436 a.a.

Protein Preferred Names

Protein Names

ATP-sensitive inward rectifier potassium channel 14

inward rectifier K(+) channel Kir2.4

Related Diseases

Diseases

Alias

Kluver-Bucy Syndrome

Bilateral Temporal Lobe Disorder	Klüver-Bucy Syndrome
Klver-Bucy Syndrome	Kluver Bucy Syndrome
Memory Loss, Extreme Sexual Behavior, Placidity, And Visual Distractibility	Post-Encephalitic Kluver Bucy Syndrome
Post-Traumatic Kluver Bucy Syndrome

Andersen Cardiodysrhythmic Periodic Paralysis

Andersen Syndrome	Andersen-Tawil Syndrome
LQT7	Long Qt Syndrome 7
Ats	Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type
Long Qt Syndrome Type 7	Andersen Tawil Syndrome
Potassium-Sensitive Cardiodysrhythmic Type	Lqts Type 7
Long Qt Syndrome-7

Severe Congenital Neutropenia 3

Kostmann Syndrome	Infantile Agranulocytosis
Kostmann Disease	Scn3
Severe Congenital Neutropenia Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07141	KCNJ14 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCNJ14	MGD	MGI:2384820
Macaca mulatta	KCNJ14	VGNC	VGNC:73985
Rattus norvegicus	KCNJ14	RGD	RGD:628872
Bos taurus	KCNJ14	VGNC	VGNC:30457

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