2. Gene
  3. ENTPD8 - ectonucleoside triphosphate diphosphohydrolase 8 Gene

ENTPD8 - ectonucleoside triphosphate diphosphohydrolase 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UNQ2492; GLSR2492; E-NTPDase; NTPDase-8

Gene ID: 377841 | Gene type: protein coding

About ENTPD8

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,434,364-137,441,357 (from NCBI)

This gene has 4 transcripts (splice variants), 171 orthologues and 7 paralogues. Biased expression in colon (RPKM 14.4), duodenum (RPKM 11.4) and 6 other tissues.

Summary

Predicted to enable guanosine-diphosphatase activity and uridine-diphosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to act upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ENTPD8 Products(2)

mRNA Protein Name
NM_001033113.2 NP_001028285.1 ectonucleoside triphosphate diphosphohydrolase 8 isoform 1
NM_198585.3 NP_940987.2 ectonucleoside triphosphate diphosphohydrolase 8 isoform 2

ENTPD8 Protein Structure

GDA1_CD39

GDA1_CD39: GDA1/CD39 (nucleoside phosphatase) family (38 - 454)

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  • 495 a.a.
Protein Preferred Names Protein Names

ectonucleoside triphosphate diphosphohydrolase 8

E-NTPDase 8

Related Diseases

Diseases Alias
Spastic Paraplegia 64, Autosomal Recessive

SPG64

Hereditary Spastic Paraplegia 64

Autosomal Recessive Spastic Paraplegia Type 64

Autosomal Recessive Spastic Paraplegia 64

Paraplegia, Spastic, Type 64, Autosomal Recessive
Vasculogenic Impotence

Impotence, Vasculogenic
Trichomoniasis

Trichomonas Infection

Trichomonas Infections

Disease Due To Trichomonadidae

Infection By Trichomonas

Trichomonadosis

Trichomonas Pruritus

Trichomonosis

Tricomoniasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04401 ENTPD8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ENTPD8 VGNC VGNC:28513
Mus musculus ENTPD8 MGD MGI:1919340
Canis familiaris ENTPD8 VGNC VGNC:40386
Felis catus ENTPD8 VGNC VGNC:61884
Macaca mulatta ENTPD8 VGNC VGNC:72104
Rattus norvegicus ENTPD8 RGD RGD:1561793