2. Gene
  3. KCNN1 - potassium calcium-activated channel subfamily N member 1 Gene

KCNN1 - potassium calcium-activated channel subfamily N member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SK1; hSK1; SKCA1; KCa2.1

Gene ID: 3780 | Gene type: protein coding

About KCNN1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,951,290-18,000,085 (from NCBI)

This gene has 11 transcripts (splice variants), 275 orthologues and 3 paralogues. Biased expression in brain (RPKM 5.8), testis (RPKM 0.7) and 1 other tissue.

Summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of Potassium Channel genes. [provided by RefSeq, Jul 2008]

KCNN1 Products(5)

mRNA Protein Name
NM_001386974.1 NP_001373903.1 small conductance calcium-activated potassium channel protein 1 isoform 1
NM_001386975.1 NP_001373904.1 small conductance calcium-activated potassium channel protein 1 isoform 2
NM_001386976.1 NP_001373905.1 small conductance calcium-activated potassium channel protein 1 isoform 2
NM_001386977.1 NP_001373906.1 small conductance calcium-activated potassium channel protein 1 isoform 3
NM_002248.5 NP_002239.2 small conductance calcium-activated potassium channel protein 1 isoform 1

KCNN1 Protein Structure

SK_channel

SK_channel: Calcium-activated SK potassium channel (92 - 210)

Ion_trans_2

Ion_trans_2: Ion channel (289 - 369)

CaMBD

CaMBD: Calmodulin binding domain (384 - 463)

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  • 543 a.a.
Protein Preferred Names Protein Names

small conductance calcium-activated potassium channel protein 1

potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1

Related Diseases

Diseases Alias
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07169 KCNN1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KCNN1 VGNC VGNC:30483
Macaca mulatta KCNN1 VGNC VGNC:74002
Rattus norvegicus KCNN1 RGD RGD:2962
Mus musculus KCNN1 MGD MGI:1933993
Felis catus KCNN1 VGNC VGNC:67926
Canis familiaris KCNN1 VGNC VGNC:42284