1. Gene
  2. KCNS1 - potassium voltage-gated channel modifier subfamily S member 1 Gene

KCNS1 - potassium voltage-gated channel modifier subfamily S member 1 Gene

Homo sapiens

Also known as Kv9.1

Gene ID: 3787 | Gene type: protein coding

About KCNS1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,091,214-45,101,127 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.8), gall bladder (RPKM 1.3) and 3 other tissues.

Summary

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the Potassium Channel family. [provided by RefSeq, Jul 2008]

KCNS1 Products(2)

mRNA Protein Name
NM_001322799.2 NP_001309728.1 potassium voltage-gated channel subfamily S member 1
NM_002251.5 NP_002242.2 potassium voltage-gated channel subfamily S member 1

KCNS1 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (52 - 151)

Ion_trans

Ion_trans: Ion transport protein (275 - 456)

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  • 526 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily S member 1

delayed-rectifier K(+) channel alpha subunit 1

Related Diseases

Diseases Alias
Causalgia

Complex Regional Pain Syndrome, Type Ii

Complex Regional Pain Syndrome Type 2

Paroxysmal Extreme Pain Disorder

PEPD

Familial Rectal Pain

Pexpd

Submandibular, Ocular, And Rectal Pain With Flushing

Pain, Submandibular, Ocular, And Rectal, With Flushing

Rectal Pain, Familial

Submandibular, Ocular And Rectal Pain With Flushing

Familial Rectal Syndrome

Frp

Pain Disorder, Paroxysmal, Extreme

Erythromelalgia

Primary Erythromelalgia

Erythermalgia

Primary Erythermalgia

Mitchell Disease

Familial Erythromelalgia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus KCNS1 VGNC VGNC:30491
Mus musculus KCNS1 MGD MGI:1197019
Rattus norvegicus KCNS1 RGD RGD:621524
Felis catus KCNS1 VGNC VGNC:67932
Canis familiaris KCNS1 VGNC VGNC:42293
Macaca mulatta KCNS1 VGNC VGNC:84919