1. Gene
  2. KCNS3 - potassium voltage-gated channel modifier subfamily S member 3 Gene

KCNS3 - potassium voltage-gated channel modifier subfamily S member 3 Gene

Homo sapiens

Also known as KV9.3

Gene ID: 3790 | Gene type: protein coding

About KCNS3

Cytogenetic location: 2p24.2 Genomic coordinates (GRCh38): 2:17,877,847-17,932,958 (from NCBI)

This gene has 5 transcripts (splice variants), 255 orthologues and 31 paralogues. Broad expression in lung (RPKM 12.4), placenta (RPKM 5.3) and 18 other tissues.

Summary

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the Potassium Channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

KCNS3 Products(2)

mRNA Protein Name
NM_001282428.2 NP_001269357.1 potassium voltage-gated channel subfamily S member 3
NM_002252.5 NP_002243.3 potassium voltage-gated channel subfamily S member 3

KCNS3 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (17 - 116)

Ion_trans

Ion_trans: Ion transport protein (225 - 405)

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  • 491 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily S member 3

Shab-related delayed-rectifier K+ channel alpha subunit 3

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy 52

DEE52

Epileptic Encephalopathy, Early Infantile, 52

Eiee52

Developmental And Epileptic Encephalopathy, 52

Early Infantile Epileptic Encephalopathy 52

Gallbladder Benign Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus KCNS3 VGNC VGNC:30493
Felis catus KCNS3 VGNC VGNC:80501
Macaca mulatta KCNS3 VGNC VGNC:74010
Rattus norvegicus KCNS3 RGD RGD:621527
Mus musculus KCNS3 MGD MGI:1098804
Canis familiaris KCNS3 VGNC VGNC:103687