KHK - ketohexokinase Gene

Homo sapiens

Also known as FRUCTU

Gene ID: 3795 | Gene type: protein coding

About KHK

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,086,772-27,100,762 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 77.2), liver (RPKM 59.5) and 2 other tissues.

Summary

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first Enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

KHK Products(2)

mRNA	Protein	Name
NM_000221.3	NP_000212.1	ketohexokinase isoform a
NM_006488.3	NP_006479.1	ketohexokinase isoform b

KHK Protein Structure

PfkB

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

ketohexokinase

fructokinase

Recombinant KHK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70146	Ketohexokinase/KHK Protein, Human (HEK293, His)	AAH06233.1 (M1-V298)	≥95%

Related Diseases

Diseases

Alias

Fructosuria, Essential

Essential Fructosuria	Ketohexokinase Deficiency
Fructosuria	Hepatic Fructokinase Deficiency
Fructokinase Deficiency	FRUCT
Deficiency Of Fructokinase

Advanced Sleep Phase Syndrome, Familial, 3

Advanced Sleep Phase Syndrome 3	FASPS3
Familial Advanced Sleep Phase Syndrome 3	Sleep Phase Syndrome, Advanced, Familial, Type 3

Basidiobolomycosis

Infection By Basidiobolus

Subcutaneous Mucoromycosis Due To Basidiobolus Ranarum

Retinitis Pigmentosa 62

RP62	Retinitis Pigmentosa, Type 62

Lumbosacral Lipoma

Fructose Intolerance, Hereditary

Hereditary Fructose Intolerance	Fructose Intolerance
Fructose-1-Phosphate Aldolase Deficiency	Fructose-1,6-Bisphosphate Aldolase B Deficiency
Aldolase B Deficiency	Fructosemia
Aldob Deficiency	Hereditary Fructose Intolerance Syndrome
HFI	Fructosaemia
Hereditary Fructose-1-Phosphate Aldolase Deficiency	Fructose Aldolase B Deficiency
Fructose-1,6-Biphosphate Aldolase Deficiency	Hereditary Fructosemia
Fructosemia, Hereditary	Hereditary Fructosaemia
Fructose-Biphosphate Aldolase B Deficiency	Fructose Intolerance Of Newborn
Aldb - [Aldolase B] Deficiency	Deficiency Of Fructose-Bisphosphate Aldolase

Renal Artery Atheroma

Atherosclerosis Of Renal Artery	Renal Atherosclerosis
Atherosclerotic Renal Disease	Ras - [Renal Artery Stenosis]
Renal Arterial Arteriosclerosis	Renal Arterial Arteriosclerotic Disease
Renal Arterial Stricture	Renal Artery Stricture
Renal Artery Stenosis Of Unknown Cause	Renal Artery Stenosis Due To Atherosclerosis
Renal Artery Stenosis	Renal Artery Arteriosclerotic Disease
Renal Artery Arteriosclerosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17613	Evocalcet	Activator	98.39%	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9925	Brodalumab	Inhibitor	97.23%	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103478	KHK-IN-2	Inhibitor	99.75%	Unkown
HY-12841A	KHK-IN-1 hydrochloride	Inhibitor	98.47%	Unkown
HY-149987	LY3522348	Inhibitor	99.31%	Unkown
HY-12841	KHK-IN-1	Inhibitor	/	Unkown
HY-149605	KHK-IN-4	Inhibitor	/	Unkown
HY-RS07240	KHK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KHK	VGNC	VGNC:42338
Felis catus	KHK	VGNC	VGNC:67937
Rattus norvegicus	KHK	RGD	RGD:2966
Macaca mulatta	KHK	VGNC	VGNC:74014
Mus musculus	KHK	MGD	MGI:1096353
Bos taurus	KHK	VGNC	VGNC:30543
Others	KHK	NCBI

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