KPNA3 - karyopherin subunit alpha 3 Gene

Homo sapiens

Also known as SRP1; SRP4; IPOA4; SPG88; hSRP1; SRP1gamma

Gene ID: 3839 | Gene type: protein coding

About KPNA3

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,699,320-49,792,682 (from NCBI)

This gene has 2 transcripts (splice variants), 232 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 17.5), brain (RPKM 15.2) and 25 other tissues.

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

KPNA3 Products(1)

mRNA	Protein	Name
NM_002267.4	NP_002258.2	importin subunit alpha-4

KPNA3 Protein Structure

IBB

Arm

0
100
200
300
400
521 a.a.

Protein Preferred Names

Protein Names

importin subunit alpha-4

SRP1-gamma

Related Diseases

Diseases

Alias

Spastic Paraplegia 37, Autosomal Dominant

SPG37	Autosomal Dominant Spastic Paraplegia Type 37
Hereditary Spastic Paraplegia 37	Autosomal Dominant Spastic Paraplegia 37

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07417	KPNA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KPNA3	VGNC	VGNC:67975
Rattus norvegicus	KPNA3	RGD	RGD:1311339
Canis familiaris	KPNA3	VGNC	VGNC:42501
Macaca mulatta	KPNA3	VGNC	VGNC:74200
Mus musculus	KPNA3	MGD	MGI:1100863
Bos taurus	KPNA3	VGNC	VGNC:30702

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