2. Gene
  3. KPNA4 - karyopherin subunit alpha 4 Gene

KPNA4 - karyopherin subunit alpha 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as QIP1; SRP3; IPOA3

Gene ID: 3840 | Gene type: protein coding

About KPNA4

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:160,495,007-160,565,571 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in heart (RPKM 11.7), esophagus (RPKM 9.8) and 25 other tissues.

Summary

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and DOCK NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

KPNA4 Products(1)

mRNA Protein Name
NM_002268.5 NP_002259.1 importin subunit alpha-3

KPNA4 Protein Structure

IBB

IBB: Importin beta binding domain (4 - 93)

Arm

Arm: Armadillo/beta-catenin-like repeat (104 - 144)

Arm

Arm: Armadillo/beta-catenin-like repeat (146 - 184)

Arm

Arm: Armadillo/beta-catenin-like repeat (189 - 229)

Arm

Arm: Armadillo/beta-catenin-like repeat (233 - 271)

Arm

Arm: Armadillo/beta-catenin-like repeat (274 - 312)

Arm

Arm: Armadillo/beta-catenin-like repeat (315 - 355)

Arm

Arm: Armadillo/beta-catenin-like repeat (357 - 396)

Arm

Arm: Armadillo/beta-catenin-like repeat (402 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 521 a.a.
Protein Preferred Names Protein Names

importin subunit alpha-3

importin alpha Q1

Related Diseases

Diseases Alias
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07418 KPNA4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KPNA4 VGNC VGNC:42502
Macaca mulatta KPNA4 VGNC VGNC:74201
Bos taurus KPNA4 VGNC VGNC:30703
Mus musculus KPNA4 MGD MGI:1100848
Rattus norvegicus KPNA4 RGD RGD:1311483
Felis catus KPNA4 VGNC VGNC:67976