KRT16 - keratin 16 Gene

Homo sapiens

Also known as K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A

Gene ID: 3868 | Gene type: protein coding

About KRT16

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,609,778-41,612,767 (from NCBI)

This gene has 4 transcripts (splice variants), 85 orthologues, 68 paralogues and is associated with 7 phenotypes. Biased expression in skin (RPKM 209.9) and esophagus (RPKM 198.8).

Summary

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]

KRT16 Products(1)

mRNA	Protein	Name
NM_005557.4	NP_005548.2	keratin, type I cytoskeletal 16

KRT16 Protein Structure

Filament

0
100
200
300
400
473 a.a.

Protein Preferred Names

Protein Names

keratin, type I cytoskeletal 16

cytokeratin 16

Related Diseases

Diseases

Alias

Pachyonychia Congenita 1

Pachyonychia Congenita	Jadassohn-Lewandowsky Syndrome
Pachyonychia Congenita Syndrome	PC1
Pachyonychia Congenita, Jadassohn-Lewandowsky Type	Congenital Pachyonychia
Pachyonychia Congenita, Type 1	Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly
Jadassohn-Lewandowsky Syndrome, Formerly	Jackson-Lawler Type Pachyonychia Congenita
Pachyonychia Congenita Type 1	Jackson-Lawler Syndrome
Jadassohn-Lewandowski Syndrome	Pc
Pachyonychia Congenita Jackson-Lawler Type	Pachyonychia Congenita Jadassohn-Lewandowsky Type
Pachyonychia Congenita Jackson Lawler Type	Pc-1
Pachyonychia Congenita, Jadassohn Lewandowsky Type	Pachyonychia Congenita, Type 2

Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma	Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma
FNEPPK1	Ppkfne
Keratoderma, Focal Nonepidermolytic Palmoplantar	Palmoplantar Keratoderma, Nonepidermolytic, Focal
Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas	Fneppk
Focal Nonepidermolytic Palmoplantar Keratoderma 1	Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1
Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1

Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma	EPPK
Keratosis Palmaris Et Plantaris Familiaris	Tylosis
Keratosis Of Greither	Diffuse Nonepidermolytic Palmoplantar Keratoderma
Keratoderma, Palmoplantar, Epidermolytic	Unna-Thost Palmoplantar Keratoderma
Epidermolytic Palmoplantar Keratoderma Of Voerner	Ppke
Keratoderma, Epidermolytic Palmoplantar	Palmoplantar Keratoderma, Vorner Type
Hyperkeratosis, Localized Epidermolytic	Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type
Epidermolytic Palmoplantar Keratoderma Of Vörner	Hyperkeratosis Palmoplantar Localized Epidermolytic
Diffuse Neppk	Ppk Diffusa Circumscripta
Thost-Unna Disease	Thost-Unna Palmoplantar Keratoderma
Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type	Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type
Epidermolytic Palmoplantar Keratoderma Of Vorner	Ehppk
Epidermolytic Unna-Thost Disease	Localized Epidermolytic Hyperkeratosis
Palmoplantar Keratoderma Vorner Type	Unilateral Palmoplantar Verrucous Nevus
UPVN	Keratoderma, Palmoplantar, Diffuse
Hyperkeratosis	Palmoplantar Keratoderma, Nonepidermolytic
Epidermolytic Palmoplantar Keratoderma Vorner Type	Type B Tylosis
Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas	Type A Tylosis

Contact Dermatitis

Contact Dermatitis/Eczema	Contact Eczema
Dermatitis Venenata	Dermatitis, Venenata
Dermatitis Contact	Dermatitis, Contact

Bowen'S Disease

Bowens Disease

Palmoplantar Keratoderma, Nonepidermolytic

Nonepidermolytic Palmoplantar Keratoderma	NEPPK
Tylosis	Unna-Thost Syndrome
Keratoderma, Palmoplantar, Diffuse	Ppkne
Keratoderma, Nonepidermolytic Palmoplantar	Diffuse Nonepidermolytic Palmomplantar Keratoderma
Thost-Unna Syndrome	Non-Epidermolytic Palmoplantar Keratoderma
Autosomal Dominant Diffuse Palmoplantar Keratoderma, Norrbotten Type	Diffuse Palmoplantar Keratoderma, Bothnian Type
Krt1-Related Diffuse Nonepidermolytic Keratoderma	Krt1-Related Diffuse Neppk
Keratoderma, Palmoplantar, Non-Epidermolytic	Nonepidermolytic Unna-Thost Disease
Non-Epidermolytic Unna-Thost Disease	Keratoderma, Palmoplantar, Nonepidermolytic
Hyperkeratosis

Steatocystoma Multiplex

Sebocystomatosis	Multiple Sebaceous Cysts
Multiplex Steatocystoma	Sebaceous Cysts, Multiple
SM

Epidermolytic Hyperkeratosis

Bullous Congenital Ichthyosiform Erythroderma	Bullous Ichthyosiform Erythroderma
EHK	Bullous Erythroderma Ichthyosiformis Congenita Of Brocq
Bcie	Bie
Epidermolytic Ichthyosis	Ichthyosis Bullosa Of Siemens
Superficial Epidermolytic Ichthyosis	Hyperkeratosis, Epidermolytic
Congenital Bullous Ichthyosiform Erythroderma	Bullous Type Ichthyosis
Epidermolytic Palmoplantar Hyperkeratosis	Bullous Ichthyosiform Erythroderma Congenita
Bullous Erythroderma Ichthyosiforme	Sei
Epidermolytic Hyperkeratosis Late-Onset	Epidermolytic Hyperkeratosis, Late-Onset

Pachyonychia Congenita 2

Pachyonychia Congenita, Type 2	PC2
Pachyonychia Congenita, Jackson-Lawler Type, Formerly	Pachyonychia Congenita Jackson-Lawler Type

Palmoplantar Keratosis

Palmoplantar Keratoderma	Keratosis Palmaris Et Plantaris
Palmo-Plantar Keratodermas	Keratoderma, Palmoplantar
Keratoderma Palmoplantar	Keratoderma, Palmoplantar, Diffuse
Hyperkeratosis Of Palms And Soles	Palmoplantar Hyperkeratosis

Hypertrophic Scars

Scars Hypertrophic

Hypertrophic Scarring

Psoriasis

Monilethrix

Beaded Hair	MNLIX
Nodose Hair	Moniliform Hair Syndrome

Cholesteatoma Of Middle Ear

Cholesteatoma	Epidermosis Of Ear
Epidermosis Of Middle Ear	Middle Ear Cholesteatoma
Cholesteatoma Of Middle Ear And Mastoid	Cholesteatoma Of Middle Ear And/Or Mastoid
Cholesteatoma Of The Middle Ear	Congenital Cholesteatoma
Primary Acquired Cholesteatoma	Secondary Acquired Cholesteatoma
Cholesteatoma Middle Ear	Cholesteatoma, Middle Ear
Cholesterolosis Of Middle Ear	Cholesterosis Of Ear
Cholesterosis Of Middle Ear	Cholesteatoma Nos
Epidermoid Cholesteatoma	Middle Ear Granuloma

Focal Palmoplantar Keratoderma

Focal Ppk	Focal Keratosis Palmoplantaris
Focal Palmoplantar Hyperkeratosis

Keratosis

Actinic Keratosis

Hyperkeratosis

Epidermolysis Bullosa Simplex

Ebs	Epidermolysis Bullosa Intraepidermic
Epidermolytic Epidermolysis Bullosa

Lichen Planus

Lichen Ruber Planus	Lichen, Ruber Planus
Ruber Planus	Lp - [Lichen Planus]
Lichen Planus Of Wilson	Wilson Lichen Ruber

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Epidermolysis Bullosa

Acantholysis Bullosa

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

PPKNEFD	Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma
Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering	Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse
Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse

Keratoacanthoma

Ka - [Keratoacanthoma]

Well-Differentiated Squamous Cell Carcinoma

Glossitis

Inflammation Of Tongue	Tongue Inflammation
Glazed Tongue

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Alopecia Areata

Aa	Alopecia Celsi
Alopecia Circumscripta	Cazenave'S Vitiligo
Celsus' Vitiligo	Diffuse Alopecia
Jonston'S Alopecia	Marginal Alopecia
Pseudopelade	Circumscribed Alopecia
Alopecia Cicatrisata	Patchy Alopecia
Alopecia	Aa - [Alopecia Areata]
Pelade

Corneal Dystrophy

Irritant Dermatitis

Irritant Contact Dermatitis	Primary Irritant Dermatitis
Dermatitis, Irritant	Contact Dermatitis, Irritant
Irritant Contact Eczema	Icd - [Irritant Contact Dermatitis]
Irritant Contact Dermatitis, Unspecified Cause	Non-Allergic Contact Dermatitis
Irritant Contact Eczema Due To Wet Work	Irritant Contact Dermatitis Due To Detergents
Irritant Contact Eczema Due To Solvents	Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants
Irritant Contact Eczema Due To Cosmetics Or Emollients	Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials
Irritant Contact Eczema Due To Plants Or Other Vegetable Matter	Irritant Contact Eczema Due To Foods
Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids	Irritant Contact Eczema Due To Saliva
Irritant Contact Eczema Due To Incontinence	Incontinence-Associated Dermatitis

Epidermolysis Bullosa Simplex Localized Type

Epidermolysis Bullosa Simplex, Weber-Cockayne Type	Weber-Cockayne Syndrome
Ebs-Loc	Epidermolysis Bullosa Simplex Of Palms And Soles
Epidermolysis Bullosa Simplex Weber-Cockayne Type	Epidermolysis Bullosa Simplex, Localized
Epidermolysis Bullosa Of Hands And Feet	Weber-Cockayne Type Epidermolysis Bullosa Simplex
Localized Epidermolysis Bullosa Simplex	Localized Ebs

Autoimmune Disease Of Skin And Connective Tissue

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07439	KRT16 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT16	MGD	MGI:96690
Rattus norvegicus	KRT16	RGD	RGD:1590901
Macaca mulatta	KRT16	VGNC	VGNC:74210