FRRS1 - ferric chelate reductase 1 Gene

Homo sapiens

Also known as SDR2; SDFR2

Gene ID: 391059 | Gene type: protein coding

About FRRS1

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:99,703,970-99,766,635 (from NCBI)

This gene has 5 transcripts (splice variants), 224 orthologues and 2 paralogues. Broad expression in liver (RPKM 6.9), placenta (RPKM 5.3) and 22 other tissues.

Summary

Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]

FRRS1 Products(2)

mRNA	Protein	Name
NM_001013660.4	NP_001013682.2	ferric-chelate reductase 1 isoform 1 precursor
NM_001361041.2	NP_001347970.1	ferric-chelate reductase 1 isoform 2 precursor

FRRS1 Protein Structure

Reeler

DOMON

0
100
200
300
400
500
626 a.a.

Protein Preferred Names

Protein Names

ferric-chelate reductase 1

SDR-2

Related Diseases

Diseases

Alias

Lice Infestation

Pediculosis	Louse Infestation
Mixed Pediculosis	Lice Infestations
Infestation By Pediculus	Mixed Pediculosis Infestation
Pediculosis + Lice	Pediculosis And Phthirus Infection
Pediculosis And Phthirus Infections	Pediculosis And Phthirus Infestation
Infestation By Anoplura	Pediculus Infestation
Lice Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05110	FRRS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05111	FRRS1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FRRS1	VGNC	VGNC:62367
Canis familiaris	FRRS1	VGNC	VGNC:40985
Rattus norvegicus	FRRS1	RGD	RGD:1306883
Macaca mulatta	FRRS1	VGNC	VGNC:72795
Mus musculus	FRRS1	MGD	MGI:108076

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