MUC21 - mucin 21, cell surface associated Gene

Homo sapiens

Also known as MUC-21; KMQK697; C6orf205

Gene ID: 394263 | Gene type: protein coding

About MUC21

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,983,718-30,989,903 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele and 29 orthologues. Restricted expression toward esophagus (RPKM 485.6).

Summary

This gene encodes a large membrane-bound glycoprotein which is a member of the Mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular Mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The Mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 Amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017]

MUC21 Products(3)

mRNA	Protein	Name
NM_001010909.5	NP_001010909.2	mucin-21 isoform 1 precursor
NM_001322370.2	NP_001309299.1	mucin-21 isoform 2 precursor
NM_001322371.2	NP_001309300.2	mucin-21 isoform 3 precursor

MUC21 Protein Structure

Epiglycanin_TR

Epiglycanin_C

0
100
200
300
400
500
566 a.a.

Protein Preferred Names

Protein Names

mucin-21

epiglycanin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08840	MUC21 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MUC21	MGD	MGI:3779983

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