2. Gene
  3. APOBEC4 - apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Gene

APOBEC4 - apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C1orf169

Gene ID: 403314 | Gene type: protein coding

About APOBEC4

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,646,275-183,653,316 (from NCBI)

This gene has 2 transcripts (splice variants) and 97 orthologues. Restricted expression toward testis (RPKM 6.1).

Summary

This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral Infection. [provided by RefSeq, Jul 2008]

APOBEC4 Products(1)

mRNA Protein Name
NM_203454.3 NP_982279.1 putative C->U-editing enzyme APOBEC-4

APOBEC4 Protein Structure

APOBEC_N

APOBEC_N: APOBEC-like N-terminal domain (55 - 232)

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  • 367 a.a.
Protein Preferred Names Protein Names

putative C->U-editing enzyme APOBEC-4

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)

Related Diseases

Diseases Alias
Immunodeficiency With Hyper-Igm, Type 2

HIGM2

Hyper-Igm Syndrome Type 2

Hyper-Igm Syndrome 2

Immunodeficiency With Hyper-Igm Type 2

Activation-Induced Cytidine Deaminase Deficiency

Aid Deficiency

Immunodeficiency With Hyper Igm Type 2

Hyper Igm Syndrome 2

Immunodeficiency With Hyper-Igm 2

Hyper-Igm Immunodeficiency Type 2

Immunodeficiency, With Hyper Igm, Type 2

Hyper-Igm Immunodeficiency Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00842 APOBEC4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta APOBEC4 VGNC VGNC:69936
Mus musculus APOBEC4 MGD MGI:1918531
Canis familiaris APOBEC4 VGNC VGNC:37997
Felis catus APOBEC4 VGNC VGNC:59854
Bos taurus APOBEC4 VGNC VGNC:26029
Rattus norvegicus APOBEC4 RGD RGD:1560256