2. Gene
  3. LRCH4 - leucine rich repeats and calponin homology domain containing 4 Gene

LRCH4 - leucine rich repeats and calponin homology domain containing 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LRN; LRRN1; LRRN4; PP14183

Gene ID: 4034 | Gene type: protein coding

About LRCH4

This gene has 10 transcripts (splice variants), 92 orthologues and 31 paralogues. Broad expression in testis (RPKM 33.5), spleen (RPKM 31.2) and 25 other tissues.

Summary

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]

LRCH4 Products(2)

mRNA Protein Name
NM_001289934.2 NP_001276863.1 leucine-rich repeat and calponin homology domain-containing protein 4 isoform 2
NM_002319.5 NP_002310.2 leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1

LRCH4 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (74 - 126)

LRR_8

LRR_8: Leucine rich repeat (138 - 194)

LRR_1

LRR_1: Leucine Rich Repeat (206 - 226)

CH

CH: Calponin homology (CH) domain (537 - 630)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and calponin homology domain-containing protein 4

leucine rich repeat neuronal 4

Related Diseases

Diseases Alias
Brittle Cornea Syndrome 1

Brittle Cornea Syndrome

Fragilitas Oculi With Joint Hyperextensibility

Dysgenesis Mesodermalis Corneae Et Sclerae

BCS1

Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility

Ehlers-Danlos Syndrome, Type Vib, Formerly

Eds6b, Formerly

Type Vib Ehlers-Danlos Syndrome

Eds Vib

Ehlers-Danlos Syndrome Type 6b

Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility

Eds6b Formerly

Ehlers-Danlos Syndrome Type Vib Formerly

Ehlers-Danlos Syndrome Type 6

Cornea, Brittle, Syndrome

Cornea, Brittle, Syndrome, Type 1

Ehlers-Danlos Syndrome 6b
Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy

Ppcd

Maumenee Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy 1

PPCD1

Corneal Dystrophy, Hereditary Polymorphous Posterior

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Schlichting Dystrophy

Ched1

Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

Ched1, Formerly

Hereditary Polymorphus Posterior Corneal Dystrophy

Posterior Polymorphous Dystrophy

Hereditary Polymorphous Posterior Corneal Dystrophy

Dystrophy, Corneal, Posterior Polymorphous

Dystrophy, Corneal, Posterior Polymorphous, Type 1

Polymorphous Corneal Dystrophy

Corneal Endothelial Dystrophy 2
Differentiating Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07780 LRCH4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRCH4 RGD RGD:1306145
Bos taurus LRCH4 VGNC VGNC:30974
Macaca mulatta LRCH4 VGNC VGNC:74441
Canis familiaris LRCH4 VGNC VGNC:42759
Mus musculus LRCH4 MGD MGI:1917193
Felis catus LRCH4 VGNC VGNC:68086