1. Gene
  2. LRP1 - LDL receptor related protein 1 Gene

LRP1 - LDL receptor related protein 1 Gene

Homo sapiens

Also known as APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R; IGFBP-3R; IGFBP3R1

Gene ID: 4035 | Gene type: protein coding

About LRP1

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,128,483-57,213,361 (from NCBI)

This gene has 12 transcripts (splice variants), 270 orthologues, 14 paralogues and is associated with 3 phenotypes. Ubiquitous expression in fat (RPKM 73.6), ovary (RPKM 50.9) and 22 other tissues.

Summary

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by Furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

LRP1 Products(1)

mRNA Protein Name
NM_002332.3 NP_002323.2 prolow-density lipoprotein receptor-related protein 1 preproprotein

LRP1 Protein Structure

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (25 - 62)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (71 - 108)

EGF_CA

EGF_CA: Calcium-binding EGF domain (150 - 188)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (614 - 657)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (662 - 708)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (807 - 842)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (852 - 885)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (894 - 931)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (935 - 971)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (975 - 1011)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1014 - 1051)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1061 - 1097)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1104 - 1140)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1144 - 1182)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (1185 - 1221)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1356 - 1396)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1401 - 1443)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1627 - 1667)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1977 - 2017)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (2020 - 2061)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (2344 - 2386)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (2390 - 2428)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2523 - 2559)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2565 - 2600)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2604 - 2639)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2660 - 2688)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2694 - 2730)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2734 - 2769)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2772 - 2810)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2816 - 2853)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2856 - 2895)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2903 - 2939)

cEGF

cEGF: Complement Clr-like EGF-like (2962 - 2985)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (3071 - 3111)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (3114 - 3153)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (3157 - 3198)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (3202 - 3240)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (3294 - 3330)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3332 - 3369)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3373 - 3408)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3412 - 3448)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3452 - 3489)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3493 - 3531)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3535 - 3570)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3574 - 3609)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3611 - 3647)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3653 - 3690)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3740 - 3776)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (3970 - 4010)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (4013 - 4054)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (4058 - 4095)

  • 0
  • 700
  • 1400
  • 2100
  • 2800
  • 3500
  • 4200
  • 4544 a.a.
Protein Preferred Names Protein Names

prolow-density lipoprotein receptor-related protein 1

TbetaR-V/LRP-1/IGFBP-3 receptor

Related Diseases

Diseases Alias
Keratosis Pilaris Atrophicans

KPA

Burnett Schwartz Berberian Syndrome

Atrophoderma Vermiculata

Atrophoderma Vermiculatum

Folliculitis Ulerythematosa Reticulata

Atrophodermia Vermiculata

Honeycomb Atrophy

Atrophodermia Reticulata Symmetrica Faciei

AVA

Atrophodermia Reticulata

Folliculitis Ulerythematosa

Folliculitis Ulerythematosa Reticulate

Burnett Schwartz Berberian Syndrome

Keratosis Follicularis Spinulosa Decalvans

Kfsd

Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi

Keratosis Follicularis Spinulosa Decalvans, X-Linked

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Keratosis Pilaris Atrophicans Faciei
Rift Valley Fever

Rfv - [Rift Valley Fever]

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary

Keratosis

Actinic Keratosis

Hyperkeratosis

Familial Hyperlipidemia

Familial Hyperlipoproteinemia

Hyperlipidaemia

Hyperlipoproteinemias

Hyperlipidemia

Hyperlipemia

Hyperlipidemias

Migraine Without Aura

Common Migraine

Migraine With Or Without Aura, Susceptibility To

Migraine Without Aura, Susceptibility To

Acute Migraine Without Aura

Liposarcoma

Lipomatous Cancer

Amyloidosis

Amyloid Disease

Amyloid

Amyloid Degeneration

Amyloidosis Nos

Amyloid Deposition

Amyloid Infiltration

Idiopathic Amyloidosis

Hyaloid Degeneration

Lardaceous Degeneration

Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia

Familial Hyperbetalipoproteinaemia

Familial Hypercholesteremia

Fredrickson Type Iia Hyperlipoproteinemia

Fredrickson Type Iia Lipidaemia

Hyperbetalipoproteinemia

Type Ii Hyperlipidemia

Familial Hypercholesterolæmia

Familial Hypercholesterolaemia

Fh

Hypercholesterolemia Familial

Hyperlipoproteinemia Type Ii

Hypercholesterolemia, Familial

Aortic Aneurysm

Aortic Rupture

Thoracoabdominal Aortic Aneurysm, Ruptured

Ruptured Aortic Aneurysm

Aortic Aneurysms

Aortic Aneurysm Without Mention Of Rupture Nos

Ruptured Abdominal Aortic Aneurysm

Aortic Aneurysm, Ruptured

Ruptured Thoracic Aortic Aneurysm

Cerebral Amyloid Angiopathy, App-Related

Hchwad

Amyloidosis, Cerebroarterial, App-Related

Amyloidosis, Hereditary, With Cerebral Hemorrhage, Dutch Variant

Cerebral Amyloid Angiopathy, App-Related, Dutch Variant

Cerebral Amyloid Angiopathy, App-Related, Iowa Variant

Cerebral Amyloid Angiopathy, App-Related, Italian Variant

Cerebral Amyloid Angiopathy, App-Related, Flemish Variant

Cerebral Amyloid Angiopathy, App-Related, Arctic Variant

Cerebral Amyloid Angiopathy, Dutch, Italian, Iowa, Flemish, Arctic Variants

App-Related Cerebral Amyloid Angiopathy

Abetaa21g Amyloidosis

Abeta Amyloidosis, Italian Type

Abeta Amyloidosis, Arctic Type

Abeta Amyloidosis, Iowa Type

Abeta Amyloidosis, Dutch Type

Hchwa-D

Abeta Amyloidosis, Flemish Type

Abetaa21g-Related Amyloidosis

Hchwa, Flemish Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Flemish Type

Abetae22k Amyloidosis

Hchwa, Italian Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Italian Type

Abetae22g Amyloidosis

Hchwa, Arctic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Arctic Type

Abetad23n Amyloidosis

Hchwa, Iowa Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Iowa Type

Abetal34v Amyloidosis

Abeta Amyloidosis, Piedmont Type

Abetal34v-Related Amyloidosis

Hchwa, Piedmont Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Piedmont Type

Abetae22q Amyloidosis

Hchwa, Dutch Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type

CAA-APP

Amyloidosis Cerebroarterial App-Related

Amyloidosis Hereditary With Cerebral Hemorrhage Dutch Variant

Cerebral Amyloid Angiopathy App-Related Arctic Variant

Cerebral Amyloid Angiopathy App-Related Dutch Variant

Cerebral Amyloid Angiopathy App-Related Flemish Variant

Cerebral Amyloid Angiopathy App-Related Iowa Variant

Cerebral Amyloid Angiopathy App-Related Italian Variant

Familial Occipital Calcifications With Hemorrhagic Strokes Leukoencephalopathy Arterial Dysplasia Dementia

Fochs-Ladd

Hereditary Cerebral Amyloid Angiopathy Dutch Type

Hereditary Cerebral Hemorrhage With Amyloidosis Dutch Type

Hereditary Cerebral Hemorrhage With Amyloidosis Italian Type

Cerebral Hemorrhage With Amyloidosis, Hereditary, Dutch Type

Marfan Syndrome

MFS

Mfs1

Marfan'S Syndrome

Marfan Syndrome Type 1

Marfan Syndrome, Type I

Mass Phenotype

Contractural Arachnodactyly

Mass Syndrome

Octd

Overlap Connective Tissue Disease

Marfanoid Hypermobility Syndrome

Marfan Disease

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Familial Thoracic Aortic Aneurysm

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris LRP1 VGNC VGNC:42771
Rattus norvegicus LRP1 RGD RGD:1307535
Felis catus LRP1 VGNC VGNC:68087
Macaca mulatta LRP1 VGNC VGNC:74442
Bos taurus LRP1 VGNC VGNC:30986
Mus musculus LRP1 MGD MGI:96828
Canis lupus familiaris LRP1 NCBI
Others LRP1 NCBI