CTLA4 - cytotoxic T-lymphocyte associated protein 4 Gene

Canis lupus familiaris (sub-species: familiaris)

Also known as CD152

Gene ID: 403696 | Gene type: protein coding

About CTLA4

Primary_assembly 37: 12,528,644-12,590,422 forward strand.ROS_Cfam_1.0:CM025136.1

This gene has 3 transcripts (splice variants), 157 orthologues and 1 paralogue.

mRNA	Protein	Name
NM_001003106.1	NP_001003106.1	cytotoxic T-lymphocyte protein 4

IgV_CTLA-4

Protein Preferred Names

Protein Names

cytotoxic T-lymphocyte protein 4

CTLA-4	costimulatory molecule B7 receptor CD152
cytotoxic T-lymphocyte antigen 4	cytotoxic T-lymphocyte-associated antigen 4
soluble form of cytotoxic T-lymphocyte antigen 4

Cat. No.	Product Name	Accession	Purity
HY-P75320	CTLA-4 Protein, Canine (HEK293, His)	Q9GKP2 (K36-D161)	≥95%
HY-P75321	CTLA-4 Protein, Canine (HEK293, Fc)	Q9GKP2 (M1-D161)	≥95%

Approval

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9901	Ipilimumab	Inhibitor	99.88%	Unkown
HY-108829	Abatacept		≥99.0%	Unkown
HY-P9918	Tremelimumab		99.50%	Unkown

Clinical Phase

Inhibitory Antibodies (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99117	Cadonilimab		99.29%	Phase 3
HY-P99484	Botensilimab	Inhibitor	97.18%	Phase 3
HY-P990042	Gotistobart	Inhibitor	98.00%	Phase 3
HY-P99540	Tuvonralimab	Inhibitor	99.14%	Phase 3
HY-P99166	Vudalimab	Inhibitor	≥99.0%	Phase 2
HY-P99514	Zalifrelimab	Inhibitor	98.28%	Phase 2
HY-P99809	Quavonlimab	Inhibitor	≥99.0%	Phase 2
HY-P99714	Lorigerlimab	Inhibitor	/	Phase 2
HY-P99760	Nurulimab	Inhibitor	95.00%	Phase 1
HY-P99844	Davoceticept		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03299	CTLA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03300	Ctla4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03301	Ctla4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99132	Anti-Mouse CTLA-4 Antibody (9D9)		≥98.0%	Unkown
HY-P990041	Firastotug	Inhibitor	/	Unkown
HY-P990048	Muzastotug	Inhibitor	/	Unkown
HY-P99354	Bavunalimab		/	Unkown
HY-P990080	Sovipostobart	Inhibitor	/	Unkown
HY-108829A	Abatacept (powder)	Inhibitor	95.00%	Unkown

Species	Symbol	Source	ID
Homo sapiens	CTLA4	NCBI	NCBI:1493
Macaca fascicularis	CTLA4	NCBI	NCBI:102115124
Mus musculus	CTLA4	NCBI	NCBI:12477
Rattus norvegicus	CTLA4	NCBI	NCBI:63835
Macaca mulatta	CTLA4	NCBI	NCBI:705673

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