CCL3L3 - C-C motif chemokine ligand 3 like 3 Gene

Homo sapiens

Also known as LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA

Gene ID: 414062 | Gene type: protein coding

About CCL3L3

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,194,869-36,196,758 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 185 orthologues, 25 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 50.8), brain (RPKM 6.1) and 4 other tissues.

Summary

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]

CCL3L3 Products(1)

mRNA	Protein	Name
NM_001001437.4	NP_001001437.2	C-C motif chemokine 3-like 1 precursor

CCL3L3 Protein Structure

IL8

0
93 a.a.

Protein Preferred Names

Protein Names

C-C motif chemokine 3-like 1

G0/G1 switch regulatory protein 19-2

Recombinant CCL3L3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7231	LD78-beta/CCL3L1 Protein, Human	P16619 (A24-A93)	≥95%
HY-P7769	LD78-beta/CCL3L1 Protein, Human (HEK293 His)	P16619 (A24-A93)	≥95%

Related Diseases

Diseases

Alias

Fraser Syndrome 1

Fraser Syndrome	Cryptophthalmos With Other Malformations
Cryptophthalmos Syndrome	FRASRS1
Cryptophthalmos-Syndactyly Syndrome	Fraser-Francois Syndrome
Cyclopism	Meyer-Schwickerath'S Syndrome
Ulrich-Feichtiger Syndrome	Cryptophthalmos Syndactyly Syndrome
Fraser'S Syndrome	Meyer-Schwickerath Syndrome
Ullrich-Feichtiger Syndrome

Asymptomatic Dengue

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02101	CCL3L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCL3L3	MGD	MGI:98260

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