MN1 - MN1 proto-oncogene, transcriptional regulator Gene

Homo sapiens

Also known as MGCR; MGCR1; CEBALID; MGCR1-PEN; dJ353E16.2

Gene ID: 4330 | Gene type: protein coding

About MN1

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:27,748,277-27,801,756 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and is associated with 83 phenotypes. Ubiquitous expression in brain (RPKM 2.3), esophagus (RPKM 2.2) and 21 other tissues.

Summary

Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]

MN1 Products(1)

mRNA	Protein	Name
NM_002430.3	NP_002421.3	transcriptional activator MN1

Protein Preferred Names

Protein Names

transcriptional activator MN1

meningioma (disrupted in balanced translocation) 1

Related Diseases

Diseases

Alias

Cebalid Syndrome

Mn1 C-Terminal Truncation Syndrome	CEBALID
Craniofacial Defects, Dysmorphic Ears, Structural Brain Abnormalities, Expressive Language Delay, And Impaired Intellectual Development	Mctt
Mctt Syndrome	Mn1 C-Terminal Truncation Syndrome

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Rhombencephalosynapsis

Chordoma

CHDM	Notochordoma
Notochordal Sarcoma	Chordoma, Susceptibility To
Chordocarcinoma	Chordoepithelioma

Astroblastoma

Cerebral Astroblastoma

Cns Neuroblastoma With Foxr2 Activation

Central Nervous System Neuroblastoma With Foxr2 Activation	Cns Nb-Foxr2
Cns Neuroblastoma, Foxr2-Activated

Central Nervous System Neuroblastoma

Astroblastoma, Mn1-Altered

Cns High-Grade Neuroepithelial Tumors With Mn1 Alteration

Central Nervous System Germ Cell Tumor

Central Nervous System Germ Cell Tumour	Germ Cell Tumor Of The Cns
Germ Cell Tumour Of The Cns

Anaplastic Pleomorphic Xanthoastrocytoma

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Supratentorial Ependymoma

High Grade Ependymoma

Ependymal Neoplasm	Ependymal Tumors
Malignant Ependymoma	Ependymal Tumor
Anaplastic Ependymoma	Experimental Organism Malignant Ependymoma
Ependymoma Of Brain

Childhood Infratentorial Ependymoma

Pediatric Infratentorial Ependymoma

Anaplastic Ependymoma

Ependymoma, Anaplastic

Undifferentiated Ependymoma

Rela Fusion-Positive Ependymoma

Supratentorial C11orf95-Rela Fused Ependymoma

C11orf95 Fusion-Positive Supratentorial Ependymoma

Chondroid Lipoma

Pleomorphic Xanthoastrocytoma

Pxa	Pleomorphic Xantho-Astrocytoma

Polymicrogyria

Pmg

Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms	Cerebral Ventricle Neoplasm
Intraventricular Tumor Of Brain

Supratentorial Cancer

Supratentorial Neoplasms	Brain Neoplasm, Supratentorial
Malignant Supratentorial Tumor	Cancer, Supratentorial

Cerebrum Cancer

Cerebral Cancer	Neoplasm Of Cerebrum
Tumor Of Cerebrum	Malignant Neoplasm Of Cerebrum

Myxopapillary Ependymoma

Ependymoma Myxopapillary

Large Congenital Melanocytic Nevus

Giant Pigmented Hairy Nevus	Giant Congenital Melanocytic Nevus
Gmn	Congenital Pigmented Nevus
Lcmn	Gphn
Giant Congenital Nevus	Bathing Trunk Nevus
Congenital Giant Pigmented Nevus	Congenital Hairy Nevus
Giant Hairy Nevus	Giant Pigmented Nevus
Congenital Giant Pigmented Nevus Of Skin	Congenital Melanocytic Nevus Syndrome
Giant Congenital Melanocytic Nevi	Giant Congenital Pigmented Nevus
Melanocytic Nevus Syndrome, Congenital

Pineal Gland Cancer

Tumor Of The Pineal Region	Malignant Pineal Region Tumor
Malignant Tumor Of Pineal Gland	Neoplasm Of Pineal Gland
Neoplasm Of The Pineal Region	Pineal Body Neoplasm
Pineocytic Tumor	Malignant Neoplasm Of Pineal Gland
Pineal Gland Neoplasm	Pineocytoma

Tanycytic Ependymoma

Chordoid Glioma

Chordoid Glioma Of The Third Ventricle

Embryonal Tumor With Multilayered Rosettes, C19mc-Altered

Ependymoblastoma

Gaucher Disease, Type Ii

GD2	Gd Ii
Gaucher Disease, Acute Neuronopathic Type	Gaucher Disease Type 2
Gaucher Disease Type Ii	Gaucher'S Disease Type Ii
Infantile Cerebral Gaucher Disease	Acute Neuronopathic Gaucher Disease
Gd 2	Gaucher Disease, Infantile Cerebral
Gaucher Disease 2	Type 2 Gaucher Disease
Gaucher Disease, Type 2

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99584	Suvizumab	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19378	MIV-150	Inhibitor	/	Unkown
HY-RS08565	MN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MN1	VGNC	VGNC:107802
Rattus norvegicus	MN1	RGD	RGD:1565571
Bos taurus	MN1	VGNC	VGNC:31536
Canis familiaris	MN1	VGNC	VGNC:52951
Mus musculus	MN1	MGD	MGI:1261813
Others	MN1	NCBI

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