MPST - mercaptopyruvate sulfurtransferase Gene

Homo sapiens

Also known as MST; TST2; TUM1

Gene ID: 4357 | Gene type: protein coding

About MPST

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:37,019,742-37,029,815 (from NCBI)

This gene has 8 transcripts (splice variants), 124 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 33.5), liver (RPKM 30.3) and 25 other tissues.

Summary

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

MPST Products(5)

mRNA	Protein	Name
NM_001013436.4	NP_001013454.1	3-mercaptopyruvate sulfurtransferase isoform 2
NM_001130517.4	NP_001123989.1	3-mercaptopyruvate sulfurtransferase isoform 2
NM_001369904.2	NP_001356833.1	3-mercaptopyruvate sulfurtransferase isoform 2
NM_001369905.2	NP_001356834.1	3-mercaptopyruvate sulfurtransferase isoform 3
NM_021126.8	NP_066949.2	3-mercaptopyruvate sulfurtransferase isoform 1

MPST Protein Structure

Rhodanese

0
100
200
297 a.a.

Protein Preferred Names

Protein Names

3-mercaptopyruvate sulfurtransferase

human liver rhodanese

Related Diseases

Diseases

Alias

Mercaptolactate-Cysteine Disulfiduria

Disulfiduria, Mixed

MCDU

Sulfhemoglobinemia

Cystathioninuria

Cystathionase Deficiency	Gamma-Cystathionase Deficiency
Cystathione Gamma-Lyase Deficiency Syndrome	Cystathionine Gamma-Lyase Deficiency Syndrome
CSTNU

Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy	EE
Epema Syndrome	Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Ethe1 Deficiency	Eme
Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Advanced Sleep Phase Syndrome, Familial, 3

Advanced Sleep Phase Syndrome 3	FASPS3
Familial Advanced Sleep Phase Syndrome 3	Sleep Phase Syndrome, Advanced, Familial, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08630	MPST Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MPST	VGNC	VGNC:74922
Canis familiaris	MPST	VGNC	VGNC:43351
Mus musculus	MPST	MGD	MGI:2179733
Rattus norvegicus	MPST	RGD	RGD:620065
Bos taurus	MPST	VGNC	VGNC:31589