GET3 - guided entry of tail-anchored proteins factor 3, ATPase Gene

Homo sapiens

Also known as ARSA1; ASNA1; TRC40; ARSA-I; ASNA-I

Gene ID: 439 | Gene type: protein coding

About GET3

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,737,106-12,748,323 (from NCBI)

This gene has 3 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in kidney (RPKM 39.3), thyroid (RPKM 34.9) and 25 other tissues.

Summary

This gene represents the human homolog of the Bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

GET3 Products(3)

mRNA	Protein	Name
NM_001371488.1	NP_001358417.1	ATPase GET3
NM_001371489.1	NP_001358418.1	ATPase GET3
NM_004317.4	NP_004308.2	ATPase GET3

GET3 Protein Structure

ArsA_ATPase

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

ATPase GET3

arsA arsenite transporter, ATP-binding, homolog 1

Related Diseases

Diseases

Alias

Breast Adenoma

Ademoma - Breast

Nephronophthisis 1

NPHP1	Nephronophthisis, Familial Juvenile
Nph1	Nephronophthisis 1, Juvenile
Juvenile Nephronophthisis 1	Familial Juvenile Nephronophthisis 1
Nephronophthisis, Type 1

Peroxisome Biogenesis Disorder 1b

Peroxisome Biogenesis Disorder	Infantile Refsum Disease
Infantile Phytanic Acid Storage Disease	PBD1B
Refsum Disease, Infantile	Adrenoleukodystrophy, Autosomal Neonatal
Ird	Mild Pbd-Zsd
Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder	Pbd-Zsd
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Autosomal Neonatal Adrenoleukodystrophy	Refsum Disease Infantile
Peroxisome Biogenesis Disorders	Peroxisome Biogenesis Disorder, Type 1b

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05374	GET3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GET3	MGD	MGI:1928379
Rattus norvegicus	GET3	RGD	RGD:1307906
Felis catus	GET3	VGNC	VGNC:80262
Macaca mulatta	GET3	VGNC	VGNC:80258
Bos taurus	GET3	VGNC	VGNC:96696
Canis familiaris	GET3	VGNC	VGNC:102781