PIWIL3 - piwi like RNA-mediated gene silencing 3 Gene

Homo sapiens

Also known as HIWI3

Gene ID: 440822 | Gene type: protein coding

About PIWIL3

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,719,034-24,774,720 (from NCBI)

This gene has 4 transcripts (splice variants), 174 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

PIWIL3 Products(2)

mRNA	Protein	Name
NM_001008496.3	NP_001008496.2	piwi-like protein 3 isoform 1
NM_001255975.1	NP_001242904.1	piwi-like protein 3 isoform 2

PIWIL3 Protein Structure

PAZ

Piwi

0
200
400
600
800
882 a.a.

Protein Preferred Names

Protein Names

piwi-like protein 3

piwi-like 3

Related Diseases

Diseases

Alias

Anal Canal Carcinoma

Anal Canal Cancer	Anal Canal And Perianal Gland Carcinoma
Carcinoma Of The Anal Canal	Carcinoma Of Anal Canal

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10586	PIWIL3 Human Pre-designed siRNA Set A		/	Unkown

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