MYO10 - myosin X Gene

Homo sapiens

Also known as MyoX

Gene ID: 4651 | Gene type: protein coding

About MYO10

Cytogenetic location: 5p15.1 Genomic coordinates (GRCh38): 5:16,661,907-16,936,288 (from NCBI)

This gene has 12 transcripts (splice variants), 195 orthologues and 43 paralogues. Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues.

Summary

This gene encodes a member of the Myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

MYO10 Products(1)

mRNA	Protein	Name
NM_012334.3	NP_036466.2	unconventional myosin-X

MYO10 Protein Structure

Myosin_head

MyTH4

FERM_M

0
400
800
1200
1600
2058 a.a.

Protein Preferred Names

Protein Names

unconventional myosin-X

unconventional myosin-10

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 44, With Microcephaly

MRD44	Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome
Autosomal Dominant Non-Syndromic Intellectual Disability 44	Mental Retardation, Autosomal Dominant 44
Autosomal Dominant Intellectual Developmental Disorder 44	Autosomal Dominant Intellectual Developmental Disorder 44 With Microcephaly
Autosomal Dominant Mental Retardation 44	Mental Retardation, Autosomal Dominant, Type 44

Chondrocalcinosis

Pseudogout	Calcium Pyrophosphate Deposition Disease
Familial Chondrocalcinosis	Chondrocalcinosis Nos
Cppd - [Calcium Pyrophosphate Deposition Disease]	Cpdd - [Calcium Pyrophosphate Deposition Disease]
Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site	Chondrocalcinosis, Cause Unspecified
Chondrocalcinosis Due To Pyrophosphate Crystals	Chondrocalcinosis Articularis
Calcium Pyrophosphate Arthritis And Periarthritis

Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes	ASGD5
Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes

Achondrogenesis, Type Ib

ACG1B	Achondrogenesis Type Ib
Achondrogenesis Type 1b	Achondrogenesis Ib
Achondrogenesis Fraccaro Type	Achondrogenesis, Fraccaro Type
Achondrogenesis, Parenti-Fraccaro Type	Achondrogenesis 1b
Acg-Ib	Fraccaro Achondrogenesis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08930	MYO10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MYO10	VGNC	VGNC:31811
Canis familiaris	MYO10	VGNC	VGNC:43554
Mus musculus	MYO10	MGD	MGI:107716
Rattus norvegicus	MYO10	RGD	RGD:1307193
Felis catus	MYO10	VGNC	VGNC:68387
Macaca mulatta	MYO10	VGNC	VGNC:75108

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