NEK3 - NIMA related kinase 3 Gene

Homo sapiens

Also known as HSPK36

Gene ID: 4752 | Gene type: protein coding

About NEK3

Cytogenetic location: 13q14.3 Genomic coordinates (GRCh38): 13:52,132,647-52,159,597 (from NCBI)

This gene has 11 transcripts (splice variants), 191 orthologues and 8 paralogues. Broad expression in testis (RPKM 10.8), placenta (RPKM 6.5) and 24 other tissues.

Summary

This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein differs from other NimA family members in that it is not cell cycle regulated and is found primarily in the cytoplasm. The kinase is activated by Prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. Two functional alleles for this gene have been identified in humans. The reference genome assembly (GRCh38) represents a functional allele that is associated with the inclusion of an additional coding exon in protein-coding transcripts, compared to an alternate functional allele that lacks the exon. [provided by RefSeq, Sep 2019]

NEK3 Products(3)

mRNA	Protein	Name
NM_001146099.1	NP_001139571.1	serine/threonine-protein kinase Nek3 isoform b
NM_002498.3	NP_002489.1	serine/threonine-protein kinase Nek3 isoform a
NM_152720.3	NP_689933.1	serine/threonine-protein kinase Nek3 isoform a

NEK3 Protein Structure

Pkinase

0
100
200
300
400
510 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Nek3

HSPK 36

Related Diseases

Diseases

Alias

Glycogen Storage Disease Ia

Von Gierke Disease	Glycogen Storage Disease Type I
Glycogen Storage Disease I	Hepatorenal Form Of Glycogen Storage Disease
Hepatorenal Glycogenosis	Glucose-6-Phosphatase Deficiency
Glycogen Storage Disease, Type I	Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia
GSD1A	Gsd1
Von Gierke'S Disease	Glycogen Storage Disease Type 1a
Glycogen Storage Disease 1a	Glucose-6-Phosphate Transport Defect
Gsd Ia	Deficiency Of Glucose-6-Phosphatase
Glycogenosis Type I	Glucose-6-Phosphatase Deficiency Glycogen Storage Disease
Glycogenosis Type 1	Glucose-6-Phosphate Deficiency
Gsd I	Gsd Type I
G6p Deficiency Type 1a	Gsd Due To G6p Deficiency Type 1a
Gsd Due To G6p Deficiency Type Ia	Gsd Type 1a
Gsdia	Glycogen Storage Disease Due To G6p Deficiency Type Ia
Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a	Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia
Glycogenosis Type Ia	Gsd-Ia
Storage Disease, Glycogen, Type 1a	Glycogen Storage Disease Type Ia

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09194	NEK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NEK3	VGNC	VGNC:31994
Rattus norvegicus	NEK3	RGD	RGD:1307419
Mus musculus	NEK3	MGD	MGI:1344371
Felis catus	NEK3	VGNC	VGNC:68457
Macaca mulatta	NEK3	VGNC	VGNC:75309
Others	NEK3	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.