NFATC4 - nuclear factor of activated T cells 4 Gene

Homo sapiens

Also known as NFAT3; NF-AT3; NF-ATC4

Gene ID: 4776 | Gene type: protein coding

About NFATC4

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,366,911-24,379,604 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele, 182 orthologues and 4 paralogues. Broad expression in ovary (RPKM 15.2), endometrium (RPKM 13.8) and 22 other tissues.

Summary

This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent Phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

NFATC4 Products(9)

mRNA	Protein	Name
NM_001136022.3	NP_001129494.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 1
NM_001198965.2	NP_001185894.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 3
NM_001198966.2	NP_001185895.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 4
NM_001198967.3	NP_001185896.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 5
NM_001288802.2	NP_001275731.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 6
NM_001320043.2	NP_001306972.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 7
NM_001363681.1	NP_001350610.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 8
NM_001363682.1	NP_001350611.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 9
NM_004554.5	NP_004545.2	nuclear factor of activated T-cells, cytoplasmic 4 isoform 2

NFATC4 Protein Structure

RHD_DNA_bind

TIG

0
200
400
600
800
902 a.a.

Protein Preferred Names

Protein Names

nuclear factor of activated T-cells, cytoplasmic 4

T-cell transcription factor NFAT3

Related Diseases

Diseases

Alias

Leukostasis

Noonan Syndrome With Multiple Lentigines

Leopard Syndrome	Multiple Lentigines Syndrome
Moynahan Syndrome	Cardiomyopathic Lentiginosis
Progressive Cardiomyopathic Lentiginosis	Cardio-Cutaneous Syndrome
Lentiginosis Profusa	Capute-Rimoin-Konigsmark-Esterly-Richardson Syndrome
Generalized Lentiginosis	Gorlin Syndrome Ii
Lentiginosis Profusa Syndrome	Lentigines, Electrocardiographic Conduction Abnormalities, Ocular Hypertelorism, Pulmonic Stenosis, Abnormal Genitalia, Retardation Of Growth, Deafnes
Diffuse Lentiginosis	Nsml
Familial Multiple Lentigines Syndrome	Alopecia-Epilepsy-Intellectual Disability Syndrome, Moynahan Type
Progressive Cardiomyopathic Lentiginosis Syndrome	Alopecia Epilepsy Oligophrenia Syndrome Of Moynahan

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-P0254A	Kisspeptin-10, human TFA	95.89%	Unkown
HY-P0254	Kisspeptin-10, human	99.19%	Unkown
HY-RS09242	NFATC4 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFATC4	MGD	MGI:1920431
Felis catus	NFATC4	VGNC	VGNC:68472
Rattus norvegicus	NFATC4	RGD	RGD:1310749
Bos taurus	NFATC4	VGNC	VGNC:54464
Canis familiaris	NFATC4	VGNC	VGNC:43770
Macaca mulatta	NFATC4	VGNC	VGNC:75329

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