2. Gene
  3. NHLH2 - nescient helix-loop-helix 2 Gene

NHLH2 - nescient helix-loop-helix 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HEN2; HH27; NSCL2; bHLHa34

Gene ID: 4808 | Gene type: protein coding

About NHLH2

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:115,831,344-115,841,126 (from NCBI)

This gene has 3 transcripts (splice variants), 104 orthologues, 4 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within with a positive effect on apoptotic process; hypothalamus gonadotrophin-releasing hormone neuron development; and peripheral nervous system development. Predicted to act upstream of or within several processes, including cell migration in hindbrain; male gonad development; and male mating behavior. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

NHLH2 Products(2)

mRNA Protein Name
NM_001111061.2 NP_001104531.1 helix-loop-helix protein 2
NM_005599.3 NP_005590.1 helix-loop-helix protein 2

NHLH2 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (79 - 129)

  • 0
  • 100
  • 135 a.a.
Protein Preferred Names Protein Names

helix-loop-helix protein 2

HEN-2

Related Diseases

Diseases Alias
Hypogonadotropic Hypogonadism 27 Without Anosmia

HH27
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09285 NHLH2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NHLH2 RGD RGD:1308294
Felis catus NHLH2 VGNC VGNC:107590
Bos taurus NHLH2 VGNC VGNC:32066
Mus musculus NHLH2 MGD MGI:97324
Canis familiaris NHLH2 VGNC VGNC:43799
Macaca mulatta NHLH2 VGNC VGNC:106417