NMBR - neuromedin B receptor Gene

Homo sapiens

Also known as BB1; BB1R; BRS1; NMB-R

Gene ID: 4829 | Gene type: protein coding

About NMBR

Cytogenetic location: 6q24.1 Genomic coordinates (GRCh38): 6:142,074,484-142,147,122 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 15 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

NMBR Products(3)

mRNA	Protein	Name
NM_001324307.2	NP_001311236.1	neuromedin-B receptor isoform b precursor
NM_001324308.2	NP_001311237.1	neuromedin-B receptor isoform b precursor
NM_002511.4	NP_002502.2	neuromedin-B receptor isoform a

NMBR Protein Structure

7tm_1

0
100
200
300
390 a.a.

Protein Preferred Names

Protein Names

neuromedin-B receptor

bombesin receptor 1

Related Diseases

Diseases

Alias

Breast Osteosarcoma

Osteogenic Sarcoma Of Breast

Breast Extraskeletal Osteosarcoma

Gastrinoma

Gastrin Cell Tumour	Gastrin Secreting Tumor
Malignant Gastrinoma	Gastrinoma, Malignant

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Intellectual Developmental Disorder, Autosomal Dominant 41

MRD41	Autosomal Dominant Non-Syndromic Intellectual Disability 41
Mental Retardation, Autosomal Dominant 41	Autosomal Dominant Intellectual Developmental Disorder 41
Autosomal Dominant Mental Retardation 41	Mental Retardation, Autosomal Dominant, Type 41

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116216	PD 168368	Antagonist	≥99.0%	Unkown
HY-103277A	BIM 23042 TFA	Antagonist	96.20%	Unkown
HY-P1423A	BA 1 TFA	Agonist	99.43%	Unkown
HY-103277	BIM 23042	Antagonist	/	Unkown
HY-P1423	BA 1	Agonist	/	Unkown
HY-RS09369	NMBR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NMBR	RGD	RGD:3181
Canis familiaris	NMBR	VGNC	VGNC:43855
Felis catus	NMBR	VGNC	VGNC:68502
Bos taurus	NMBR	VGNC	VGNC:32124
Mus musculus	NMBR	MGD	MGI:1100525
Macaca mulatta	NMBR	VGNC	VGNC:104416

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