NME4 - NME/NM23 nucleoside diphosphate kinase 4 Gene

Homo sapiens

Also known as NDPK-D; NM23H4; nm23-H4

Gene ID: 4833 | Gene type: protein coding

About NME4

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:396,729-400,754 (from NCBI)

This gene has 12 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in prostate (RPKM 37.4), fat (RPKM 31.4) and 25 other tissues.

Summary

The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]

NME4 Products(7)

mRNA	Protein	Name
NM_001286433.2	NP_001273362.1	nucleoside diphosphate kinase, mitochondrial isoform b
NM_001286435.2	NP_001273364.1	nucleoside diphosphate kinase, mitochondrial isoform c
NM_001286436.2	NP_001273365.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286438.2	NP_001273367.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286439.2	NP_001273368.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_001286440.2	NP_001273369.1	nucleoside diphosphate kinase, mitochondrial isoform d
NM_005009.3	NP_005000.1	nucleoside diphosphate kinase, mitochondrial isoform a precursor

NME4 Protein Structure

NDK

0
100
187 a.a.

Protein Preferred Names

Protein Names

nucleoside diphosphate kinase, mitochondrial

NDK

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09375	NME4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NME4	VGNC	VGNC:75358
Rattus norvegicus	NME4	RGD	RGD:1591334
Mus musculus	NME4	MGD	MGI:1931148

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