2. Gene
  3. NOVA2 - NOVA alternative splicing regulator 2 Gene

NOVA2 - NOVA alternative splicing regulator 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ANOVA; NOVA3; NEDASB; NOVA-2

Gene ID: 4858 | Gene type: protein coding

About NOVA2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,933,734-45,973,865 (from NCBI)

This gene has 4 transcripts (splice variants), 119 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 7.5), fat (RPKM 2.1) and 10 other tissues.

Summary

Enables sequence-specific mRNA binding activity. Involved in neuron differentiation and regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NOVA2 Products(1)

mRNA Protein Name
NM_002516.4 NP_002507.1 RNA-binding protein Nova-2

NOVA2 Protein Structure

KH_1

KH_1: KH domain (36 - 94)

KH_1

KH_1: KH domain (133 - 196)

KH_1

KH_1: KH domain (410 - 473)

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  • 492 a.a.
Protein Preferred Names Protein Names

RNA-binding protein Nova-2

astrocytic NOVA1-like RNA-binding protein

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Or Without Autistic Features And/Or Structural Brain Abnormalities

NEDASB

Neurodevelopmental Disorder With/Without Autistic Features And/Or Structural Brain Abnormalities
Paraneoplastic Polyneuropathy
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09456 NOVA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NOVA2 MGD MGI:104296
Canis familiaris NOVA2 VGNC VGNC:53745
Bos taurus NOVA2 VGNC VGNC:32181
Felis catus NOVA2 VGNC VGNC:97531
Rattus norvegicus NOVA2 RGD RGD:1308032