2. Gene
  3. NPR3 - natriuretic peptide receptor 3 Gene

NPR3 - natriuretic peptide receptor 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NPRC; ANP-C; ANPRC; BOMOS; NPR-C; ANPR-C; GUCY2B; C5orf23

Gene ID: 4883 | Gene type: protein coding

About NPR3

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:32,690,872-32,791,720 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 35.4), fat (RPKM 14.2) and 8 other tissues.

Summary

This gene encodes one of three natriuretic peptide receptors. Natriutetic Peptides are small Peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic Peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

NPR3 Products(6)

mRNA Protein Name
NM_000908.4 NP_000899.1 atrial natriuretic peptide receptor 3 isoform 2 precursor
NM_001204375.2 NP_001191304.1 atrial natriuretic peptide receptor 3 isoform 1 precursor
NM_001204376.2 NP_001191305.1 atrial natriuretic peptide receptor 3 isoform 3
NM_001363652.2 NP_001350581.1 atrial natriuretic peptide receptor 3 isoform 4
NM_001364458.2 NP_001351387.1 atrial natriuretic peptide receptor 3 isoform 5
NM_001364460.2 NP_001351389.1 atrial natriuretic peptide receptor 3 isoform 6

NPR3 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (71 - 422)

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  • 541 a.a.
Protein Preferred Names Protein Names

atrial natriuretic peptide receptor 3

atrial natriuretic peptide clearance receptor

Recombinant NPR3 Proteins

Cat. No. Product Name Accession Purity
HY-P71122 NPR3 Protein, Human (HEK293, Fc) P17342-1 (T24-E481) ≥95%

Related Diseases

Diseases Alias
Boudin-Mortier Syndrome

BOMOS

Tall Stature And Long Digits With Extra Epiphyses
Ischemic Colitis

Colitis, Ischemic

Irreversible Ischaemic Colitis
Anismus
Acromesomelic Dysplasia

Acromesomelic Dwarfism

Dysplasia, Acromesomelic

Acromesomelic Dysplasia Hunter-Thompson Type
Functional Diarrhea

Functional Diarrhoea
Acromesomelic Dysplasia 1

Acromesomelic Dysplasia, Maroteaux Type

Amdm

Acromesomelic Dysplasia 1, Maroteaux Type

AMD1

St. Helena Dysplasia

Acromesomelic Dysplasia-1

Acromesomelic Dysplasia Maroteaux Type

Acromesomelic Dwarfism Maroteux Type

Dysplasia, Acromesomelic, Type 1, Maroteaux

Acromesomelic Dysplasia Hunter-Thompson Type
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
Pulmonary Hypertension

Primary Pulmonary Hypertension

Hypertension Pulmonary

Hypertension, Pulmonary

Hypertension, Pulmonary, Primary

Idiopathic Pulmonary Hypertension

Idiopathic Pulmonary Arterial Hypertension

Pulmonary Htn - [Hypertension]
Secretory Diarrhea
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Volvulus Of Midgut

Volvulus

Intestinal Volvulus

Intestinal Malrotation, Familial

Familial Intestinal Malrotation

Twist Of Intestine, Bowel, Or Colon
Constipation
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09499 NPR3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NPR3 MGD MGI:97373
Rattus norvegicus NPR3 RGD RGD:3196
Canis familiaris NPR3 VGNC VGNC:58320
Macaca mulatta NPR3 VGNC VGNC:75390
Felis catus NPR3 VGNC VGNC:68535
Others NPR3 NCBI