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  2. NUCB2 - nucleobindin 2 Gene

NUCB2 - nucleobindin 2 Gene

Homo sapiens

Also known as NEFA; HEL-S-109

Gene ID: 4925 | Gene type: protein coding

About NUCB2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:17,276,739-17,349,980 (from NCBI)

This gene has 19 transcripts (splice variants), 279 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 51.4), salivary gland (RPKM 41.2) and 24 other tissues.

Summary

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

NUCB2 Products(14)

mRNA Protein Name
NM_001330227.3 NP_001317156.1 nucleobindin-2 isoform 2 preproprotein
NM_001352661.2 NP_001339590.1 nucleobindin-2 isoform 3 preproprotein
NM_001352662.2 NP_001339591.1 nucleobindin-2 isoform 4 preproprotein
NM_001352663.2 NP_001339592.1 nucleobindin-2 isoform 3 preproprotein
NM_001352664.2 NP_001339593.1 nucleobindin-2 isoform 1 preproprotein
NM_001352665.2 NP_001339594.1 nucleobindin-2 isoform 2 preproprotein
NM_001352666.2 NP_001339595.1 nucleobindin-2 isoform 2 preproprotein
NM_001352667.2 NP_001339596.1 nucleobindin-2 isoform 2 preproprotein
NM_001352668.2 NP_001339597.1 nucleobindin-2 isoform 1 preproprotein
NM_001352669.2 NP_001339598.1 nucleobindin-2 isoform 1 preproprotein
NM_001352670.2 NP_001339599.1 nucleobindin-2 isoform 1 preproprotein
NM_001352671.2 NP_001339600.1 nucleobindin-2 isoform 2 preproprotein
NM_001352672.2 NP_001339601.1 nucleobindin-2 isoform 1 preproprotein
NM_005013.4 NP_005004.1 nucleobindin-2 isoform 1 preproprotein

NUCB2 Protein Structure

EF-hand_7

EF-hand_7: EF-hand domain pair (248 - 321)

  • 0
  • 100
  • 200
  • 300
  • 420 a.a.
Protein Preferred Names Protein Names

nucleobindin-2

DNA-binding protein NEFA

Recombinant NUCB2 Proteins

Cat. No. Product Name Accession Purity
HY-P71177 Nucleobindin-2 Protein, Human P80303-1 (V25-L106) ≥95%

Related Diseases

Diseases Alias
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NUCB2 RGD RGD:620888
Bos taurus NUCB2 VGNC VGNC:32319
Mus musculus NUCB2 MGD MGI:1858179
Felis catus NUCB2 VGNC VGNC:68587
Macaca mulatta NUCB2 VGNC VGNC:75549
Canis familiaris NUCB2 VGNC VGNC:44020
Others NUCB2 NCBI